SABOTAGING CANCER COULD OPEN DOOR TO NEW TREATMENTS
RESEARCHERS IN EDINBURGH AIM TO ‘TRICK’ BOWEL CANCER
SCIENTISTS in Edinburgh are launching a £1.5 million Cancer Research UK-funded study to find a way to ‘sabotage’ bowel cancer cells.
Cancer cells can often disguise themselves, preventing the immune system from recognising them as a threat and destroying them. The team, at the Institute of Genetics and Cancer (IGC) at the University of Edinburgh, aims to disrupt cancer’s DNA messaging system, causing errors that make the cells visible to immune defences.
Exploring how to trigger this vulnerability, the study’s long-term goal is to identify new treatments to tackle bowel cancer more effectively.
Project leader Dr Kevin Myant, of the Cancer Research UK Scotland Centre and IGC, said:“Around 85 per cent of patients with bowel cancer find immunotherapy isn’t effective for them. Our new project aims to explore why and find new ways to make bowel cancer more responsive to this type of treatment.
“Immunotherapy is exciting as it has the potential to be curative, not just manage the disease, and has the benefit of reducing side effects to patients.
“We hope this project will find a way to shine a light on bowel cancer cells so they are no longer invisible to our immune system, by disrupting the messages telling cancer cells to grow.”
Bowel cancer kills 16,800 people in the UK (1,700 in Scotland) every year and is increasingly being diagnosed in younger people.
A recent study by the American Cancer Society published in The Lancet Oncology showed early-onset bowel cancer rates in adults aged 25-49 are rising in 27 of 50 countries studied and at a faster rate in young women in Scotland and England than in young men.
Often, in cancer, the immune system doesn’t see cancer cells as a threat as they are generated from inside the body.
This research will focus on the body’s messaging system, RNA, which takes information from DNA and tells cells when to grow and where.
The team aims to sabotage this system, through a process called RNA splicing, to disrupt these messages and introduce errors which will effectively “light up” bowel cancer cells to the immune system so it can destroy them.
Cancer Research UK Director of Research, Dr Catherine Elliott, said:“Immunotherapies, where a patient’s own immune system is harnessed to tackle cancer, are a key area of cancer research and for some patients, they are providing transformational improvements but not all patients respond to them.
“Being able to use the power of our own immune system to tackle cancer could offer more effective treatments and lead to the kind of breakthroughs which can revolutionise cancer treatment and care.
“We need more research to understand the differences in patient responses to therapies and how to improve these, and Cancer Research UK is delighted to fund this innovative and potentially transformative research.”
Bowel cancer, also known as colorectal cancer, is the second most common cause of cancer deaths in the UK. Despite this, treatment options remain limited, particularly for patients who are diagnosed at later stages of the disease.
Scotland is disproportionately affected by the disease with around 4,000 people diagnosed each year.
The Department of Clinical Neurosciences at Little France recently welcomed a news crew from CNN International to highlight a world‑leading partnership between the neurosurgery team and researchers at the University of Edinburgh.
Spearheaded by neurosurgeon Paul Brennan and Race Against Dementia Fellow Dr Claire Durrant, the programme involves keeping living human brain tissue – removed during routine neurosurgery – alive for study in the laboratory.
This pioneering research has enabled scientists to show, for the first time, how a toxic form of a protein linked to Alzheimer’s can attach to and damage the connections between brain cells.
The team hopes the discovery will help identify medications with the greatest potential to prevent the loss of synapses—the vital connections that allow messages to flow between brain cells and support healthy brain function.
Paul Brennan said: “During neurosurgery, there is always a small amount of healthy brain tissue that must be removed in order to reach, for example, a tumour and typically that tissue would be thrown away. Our partnership with Claire and her team means we can package up that healthy, living tissue and send it to the lab for testing.
“Even the tiniest piece “contains thousands of cells, and we can learn a great deal from it. Research of this type has been underway for some time, but this collaboration allows us to study living human brain tissue in a way that hasn’t routinely been possible before.”
The tissue is collected with the patient’s consent, in a process similar to organ donation. Aidan McAllister (28) chose to donate his healthy brain tissue during an operation to remove a tumour. He said: “My grandad passed away from Alzheimer’s a few years ago. We were really close – he lived just across the road and we saw each other every day. His dementia became so severe that he didn’t know who he was or who we were.
“It’s a really brutal disease. When Paul asked if I’d consider donating some of my brain tissue during surgery, I thought if it could help people like my grandad, then I wanted to do it.”
Dr Claire Durrant said: “We believe this research could accelerate the journey from lab findings to patient treatments, bringing us one step closer to a world free from the heartbreak of dementia.
“It was fantastic to be able to show the CNN team what we do and to highlight the vital, world-leading research taking place in Edinburgh.”
Researchers say previously unidentified feature of myelin couldpave the way to new treatment options
Researchers in Edinburgh have discovered that myelin, the protective coating surrounding nerves, which is damaged in multiple sclerosis (MS), could potentially repair itself instead of being lost, thanks to a newly discovered biological response.
This might offer a significant new opportunity to help slow, stop or even prevent degeneration in MS and other conditions like Alzheimer’s disease.
In MS, the immune system attacks myelin in the brain and spinal cord and disrupts messages being sent around the body. This impacts how people move, think and feel. While myelin loss is a hallmark of a range of conditions, there are still no treatments that can replace damaged or lost myelin.
Until now, research has been focused on regenerating new myelin after it has already been lost. But a team from the MS Society Edinburgh Centre for Myelin Research at the University of Edinburgh, led by Professor David Lyons and supported by international collaborators, has shown that when myelin is first damaged it undergoes a dynamic swelling phase.
This can, in principle, be followed by repair, rather than myelin loss. This potentially offers a window of opportunity to intervene before the myelin completely breaks down.
Historically, although this myelin swelling had been observed, it had not been investigated in detail, as researchers thought that it might be an artefact of the way brain tissue is preserved in the lab. But this new study took advantage of advanced technology to observe live zebrafish and tissue from mice and humans who lived with MS to follow what happened to damaged myelin over time.
The team showed that this swelling is in fact a natural process in the body that can be followed by repair of the damaged myelin, and thus one that could be a critical step in the body’s fight to prevent complete myelin loss.
This suggests that the nervous system has a powerful – and until now unrecognised – ability to withstand early myelin damage.
Professor David Lyons, Co-lead of the MS Society Edinburgh Centre for MS Research, at the University of Edinburgh, says:“These findings suggest that intervening during this early swelling phase could protect myelin before it is lost, offering us the opportunity to explore potential new treatment routes that could complement current treatments.
“For decades, scientists have focused on remyelination, the process of rebuilding myelin once it is already lost. This continues to hold promise. But now that we have this new avenue of exploration, it could be the start of something else very special.”
Over 150,000 people in the UK live with MS, with 135 diagnosed each week. More than 17,000 people with MS live in Scotland. The MS Society is the largest charitable funder of MS research in the UK. Its research has helped drive forward treatment options and dramatically improved public understanding of the condition.
The University of Edinburgh is home to one of Europe’s largest groupings of neuroscience researchers investigating the nervous system in health and disease. This includes one of two MS Society-funded Centres of Excellence in MS research.
Work at the Edinburgh Centre for MS Research, co-led by Professor Lyons and Professor Anna Williams, spans investigation of fundamental biological processes relevant to MS, drug discovery to identify treatments for MS, through clinical research and supporting clinical trials in people with disease.
Dr Emma Gray, Director of Research at the MS Society, says:“We know that the body has the ability to regenerate new myelin after it’s lost. But this study shows that existing myelin can sometimes self-heal before it’s fully lost, a process we hadn’t identified before.
“It doesn’t replace current strategies, but it adds another potential way to protect myelin early on. MS can be debilitating, exhausting and unpredictable and for tens of thousands of people there are still no treatments that work for them.
“There’s still a lot to learn, but discoveries like this are essential to help people with MS in the future.”
~ Warning not to ignore subtle stroke signs just because they are uncommon ~
A stroke survivor is warning others to watch out for unusual symptoms after joining a study funded by the British Heart Foundation.
Gordon Robb had a stroke involving a bleed in his brain, but his only symptom was finding that written words suddenly looked as if they were in a foreign language.
The 63-year-old is now taking the drug clopidogrel, as part of a clinical trial run by researchers at the University of Edinburgh. This study will examine if clopidogrel or aspirin, which are ‘antiplatelet’ drugs that reduce the risk of blood clotting, can prevent future strokes, heart attacks and premature deaths in people who have had a haemorrhagic stroke – a stroke caused by a bleed in the brain.
Gordon only discovered his stroke had happened after his cousin, whose husband had died from a stroke a few weeks earlier, insisted he go to hospital.
Having first thought his sudden inability to read was caused by tiredness, he now describes himself as an ‘extremely lucky man’. He had none of the more commonly known symptoms of a stroke, such as problems with his face, arm, speech, eyes or balance.
Difficulty recognising written words on its own, without any other symptoms, affects fewer than one per cent of people at the time of their stroke, say researchers.
A few months on, Gordon’s symptoms are improving, although it now takes him half an hour to read a chapter instead of his previous 10 minutes, and more recently he has noticed he occasionally can’t find the right word during a conversation.
Gordon said: “I am incredibly lucky, and quite honestly felt like a fraud in the stroke ward because I was no different to how I am normally, except that I suddenly could not read words.
“A group of student doctors in neurology who were brought to see me even said they would have struggled to diagnose that I had had a stroke.
“I knew some of the classic signs of a stroke like facial weakness, being unable to raise my arms or speech issues, but had none of these.
“It just shows the importance of paying attention to unusual symptoms, even if they aren’t ones you have heard of before. If I hadn’t gone to the hospital, and quickly received treatment, I could have been walking around with a ticking time-bomb in my head.”
The stroke survivor, from Bonnyrigg in Midlothian, had only been to hospital once in his life previously. A keen cyclist and runner, who had climbed to base camp at Mount Everest two years ago, he felt in perfect health.
So when, on September 27 last year, he checked his emails and could not read them, he put it down to tiredness.
Gordon, the former vice-president of a biotech company, said: “I was in the garden, went in to have a cup of tea, listen to some music and check my emails on my phone – and it was like they were in a foreign language.
“I could see them clearly, and see who they were from, but the words meant nothing to me.
“I just assumed I was tired because I had been up late the night before. When friends were then messaging me about the Ryder Cup that evening and I couldn’t see the messages, I just gave myself an early night.”
The following evening, when he was unable to read the instructions on a cash machine to withdraw money, he resolved to go to see his GP the next day.
However, when he told his cousin – whose husband had died from a sudden stroke just three weeks earlier – she drove straight to his house and insisted on taking him to A&E. There, doctors told him he had had a haemorrhagic stroke.
Approximately 15 per cent of strokes are haemorrhagic. The majority of strokes are ischaemic strokes, caused by a blocked artery.
While in hospital, Gordon signed up to a study being led by Professor Rustam Al-Shahi Salman at the University of Edinburgh, which is called ASPIRING (Antiplatelet Secondary Prevention International Randomised study after INtracerebral haemorrhaGe).
The international study is recruiting people who have had a stroke due to bleeding in the brain, also known as a haemorrhagic stroke. Study participants in the UK will be given ‘antiplatelet’ medicines like clopidogrel or aspirin, which reduce the chances of a stroke or heart attack by preventing cells in the bloodstream, called platelets, from sticking together and forming a blood clot.
Antiplatelet medicines are not routinely prescribed for people who have had a haemorrhagic stroke, because of safety concerns that they may increase the risk of bleeding. But a small study called RESTART, led by the University of Edinburgh and also funded by the British Heart Foundation, found aspirin and clopidogrel are safe after a haemorrhagic stroke.
In this new larger study, researchers in the UK now aim to understand if clopidogrel or aspirin can reduce the likelihood of having future strokes, heart attacks and other clotting and bleeding problems in people who have survived a haemorrhagic stroke.
Major clotting or bleeding problems occur in around one in 10 haemorrhagic stroke survivors every year.
Professor Salman said: “It has been hard to overcome the instinctive fear that if people have had a haemorrhagic stroke, taking aspirin or a drug like it might cause more bleeding. So we were very relieved when our research showed such drugs to be safe after a haemorrhagic stroke.
“The ASPIRING study will gather further evidence to establish if aspirin and clopidogrel can help lower the risk of future strokes and heart attacks, and potentially save the lives of people like Gordon who have had a haemorrhagic stroke.
“I believe there is a huge amount more to be done to help these people, whose lives have been turned upside down and who may be concerned about the future.”
Gordon is one of more than 4,000 people worldwide set to join the study, which is also funded by the Dutch Heart Foundation, the Canadian Institutes of Health Research, the Research Foundation – Flanders and the Medical Research Future Fund in Australia.
The study was endorsed by the Global Cardiovascular Research Funders Forum (GCRFF) multinational clinical trials initiative.
Gordon said: “Being involved in this trial provides some reassurance, that this drug may reduce my risk of another stroke.
“But it is also great to know that being involved could help improve treatment for people like me in the future, and relieve the pressure on the health system.
“I feel extremely lucky that I did not have more long-term effects from my stroke, and that I have had the chance to try to help improve treatments.”
Dr Sonya Babu-Narayan, the British Heart Foundation’s clinical director, said: “Facial weakness, arm or leg weakness and speech problems are well-known signs you or your loved one may be having a stroke, but there are some lesser-known symptoms like being unable to recognise the written word.
“If you have a symptom that you feel is not right, however strange or unusual, it is really important to seek help. Every minute matters if you may be having a stroke or other medical emergency.
“We know stroke survivors often fear having another stroke and how disabling this could be. That is why the BHF is funding clinical trials like ASPIRING, which will test whether prescribing antiplatelet drugs could protect more people.”
The ASPIRING study is recruiting people from England, Wales and Scotland who have had a haemorrhagic stroke.
Volunteers can check their eligibility, depending on the hospital where they received treatment, and express interest by visiting www.ASPIRING.ed.ac.uk
When days get shorter and temperatures drop, the natural inclination for most of us is to stay indoors and keep warm. Lara Campana, however, decided it was time to set herself the challenge of keeping active and outdoors by taking on two fundraising runs and raising £582 for the British Liver Trust!
“I’m one of the co-founders of Resolution Theraputics, based at Edinburgh University and have worked in liver disease research for over 10 years now.
I’ve seen first-hand the challenges and stigmas which patients in this community and their families endure. The British Liver Trust is there advocating for them, day in and day out; they are amazing partners to help people navigate this scary disease. So, when I took on a winter fitness challenge, it made perfect sense to support their work at the same time.”
Lara opted for two races, the Forth Road Bridge 5K in November and the Edinburgh 10K on December 7.
“I love being outside in all weathers, but it didn’t stop me catching back-to-back chest infections which have made training slightly more challenging!” she says. “However, I’m really pleased to have completed both runs and to have smashed my fundraising target!”
Audrey Cornelius, Director of Fundraising at the British Liver Trust said: “As a charity, we are leading the fight against liver disease and liver cancer. We reach over two million people each year; providing information and support to patients and families and providing vital advice to help people improve their liver health.
“But there is still so much to be done. Liver disease is the only major disease in the UK where death rates are rising, and we want to change that.
“So we’re very grateful to Lara for braving the cold and taking on these two runs – we hope she enjoyed the experience!”
Canopy Kitchen & Courtyard, part of The University of Edinburgh, is joining forces with Simpsons Special Care Babies (SSCB) to mark the charity’s 40th anniversary with a Tree of Light installation honouring families supported by the Neonatal Unit at the Royal Infirmary of Edinburgh.
The installation will be housed at Canopy Kitchen & Courtyard, the contemporary café restaurant located in the University’s Futures Institute, at the former site of Edinburgh’s Old Royal Infirmary, and will form the centrepiece of a special lighting ceremony on Saturday 29 November, creating a heartfelt moment of remembrance for families who have experienced the loss of a baby and offering a place of comfort at a time of year that can be especially difficult.
The free event, scheduled for 15:30, will welcome those who have had experiences at the Neonatal Unit – from children to their family and friends.
For many, the holiday season is a time of warmth and togetherness, yet it can also bring reflection and grief for loved ones lost. For families who have experienced the loss of a baby, the Tree of Light will stand until early January as a symbol of remembrance and healing.
With 1 in 8 babies requiring the Neonatal Unit’s support, it is hoped that the funds raised through this event will enable SSCB to purchase state-of-the-art equipment, support continued neonatal staff training and provide essential support to families during challenging times.
Tracey Ritchie, Assistant Head of Catering Operations, expressed her pride in hosting this event: “At Canopy, we’re proud to create a warm, welcoming space where people can relax and feel cared for.
“Being based in the former Simpson Memorial Maternity Hospital makes hosting this event especially meaningful. We know this time of year can be emotional, and we’re honoured to offer Simpson’s families a place to pause, reflect and remember.
“Having the Tree of Light here, in a building so deeply connected to the charity’s past, feels like a fitting way to mark their 40th year. We’re delighted to host it and look forward to supporting Simpsons Special Care Babies in the months ahead.”
Those interested in supporting this cause can donate to SSCB through their website.
Free tickets must be booked in advance through the charity’s website.
~ Next-generation bedside devices, providing a result within 15 minutes, ease pressure on overcrowded emergency departments ~
People can find out if they are having a heart attack far faster using innovative tests, according to research supported by the British Heart Foundation and presented at the American Heart Association Scientific Sessions conference in New Orleans.
When someone with chest pain attends hospital as an emergency patient , they are given a blood test for troponin – the telltale protein released into the blood when the heart is damaged, which indicates whether they have had a heart attack.
But doctors say that the test result from blood sent to the laboratory is often not available when they first need it to help make decisions for patients, and a result can sometimes take as long as two hours.
A new study, led from Christchurch Hospital in New Zealand in collaboration with BHF-funded researchers at the University of Edinburgh, investigated the performance of a new type of troponin test. Blood is placed directly onto a cartridge, and analysed on the spot, with some models of the test able to reveal if someone has had a heart attack within 15 to 20 minutes.
In the study, people given a rapid test were admitted to a ward or sent home 47 minutes faster, depending on whether it indicated they had experienced a heart attack, researchers found. This shorter stay in the emergency department, which was the average across six hospitals, was seen in comparison to troponin tests in the lab.
The new tests, produced by various technology firms, are already in use within some British hospitals and could help to tackle long waits and overcrowding within the NHS. Researchers say they could potentially also be used in GP surgeries and chest pain clinics, potentially helping to identify people whose heart attacks might otherwise have been missed.
Nicholas Mills, BHF Professor of Cardiology at the University of Edinburgh and a consultant interventional cardiologist at Edinburgh Royal Infirmary, helped to design the study, conducted in New Zealand.
Professor Mills said: “When people go to the emergency department fearing they have had a heart attack, a blood sample is taken and sent to another part of the hospital for analysis in a lab.
By the time the results are available, it is likely the doctor or nurse will have been called away, so there are unfortunate and unintended delays in making decisions for patients.
“The average turnaround for a lab troponin test can be as long as two hours, so tests which can be performed in real-time within minutes are far better for patients, reducing anxiety as they wait for an answer on what is happening to them.
“Crucially, these tests could also ease some of the pressure on overcrowded emergency departments, helping people move through more quickly.”
Troponin is a protein found in the muscles, including the heart. When the heart is injured or damaged, such as during a heart attack, troponin is released into the blood.
Hospitals used to routinely test people twice for troponin, to measure changing levels of the protein and establish if they had a heart attack. But the process was sped up, moving people through emergency departments an average of three hours faster, thanks to previous research led by the University of Edinburgh.
This showed just one troponin test could effectively identify people who were at high risk of having had a heart attack, and also the people at lower risk who could safely be sent home.
This approach was used in the current study, but, to deliver answers to patients even more quickly, researchers investigated the new generation of devices which can analyse troponin levels in the blood on the spot.
The study included almost 60,000 people attending an emergency department in New Zealand between February 2023 and January 2025. A faster test was given to 31,392 patients, while the rest had the standard test with blood samples sent to the laboratory.
Those given a rapid test, compared to the lab-based test, had a 13 per cent shorter stay in the emergency department on average. That meant they were discharged or admitted to a hospital ward an average of 47 minutes faster.
The calculation was made after taking into account other factors affecting how long people wait, such as the time of year and time of day.
Researchers tracked all the people in their study for 30 days after they visited the emergency department, finding that the rate of people dying from cardiovascular disease or having a heart attack in that time was similar whether they were given a fast test or the regular test.
This suggests a faster test is a safe way to decide if people should be admitted to a ward or discharged, which should not put people at extra risk by missing their heart attacks.
The test involves a drop of blood, from a standard blood test, being placed on a cartridge which is inserted into the device. The level of troponin then appears on the screen, helping a doctor to provide a diagnosis.
People who have not had a heart attack can be quickly reassured, thanks to a faster test. Those who have had a heart attack can receive earlier treatment with blood-thinners and be admitted directly to a specialist ward for treatment, which may include a procedure to restore the blood supply to the heart. Early treatment reduces the risk of lasting heart damage.
Dr Sonya Babu-Narayan, clinical director at the British Heart Foundation and consultant cardiologist, said: “Every minute matters if you are having a heart attack. And if you aren’t, you will want to be reassured or diagnosed with something different as soon as possible.
“Troponin is the telltale protein which leaks into the bloodstream when the heart is damaged, so measuring it can be crucial for doctors to diagnose or rule out heart attacks.
“But laboratory results can take hours to come back. So, it’s exciting to see that the bedside troponin test used in this study had a faster turnaround – providing results within minutes, and without compromising accuracy and safety.
“Reducing delays in diagnosis is vital for patients, and also important for pressurised emergency departments working to ensure everyone gets the care they need, when they need it.”
More than 100 pupils from 13 schools transformed into world leaders at the University of Edinburgh last week, engaging in high-stakes climate crisis negotiations to mirror the upcoming UN COP30 conference in Belém, Brazil.
In a United Nations debate simulation organised by the British Council in partnership with the University of Edinburgh and Learning for Sustainability Scotland, students experienced firsthand the complex challenges of international climate diplomacy.
Using cutting-edge simulation software developed by MIT, the pupils took on roles as delegates from major nations, corporate lobbyists, and international media representatives, all working to tackle the critical goal of keeping global warming below 1.5°C.
During the negotiations, the pupils had to collectively agree on how much to reduce greenhouse gas emissions, how they would help struggling nations, and agree on ways to adapt to climate change to protect their cities and people.
Leading the negotiations were pupils Siri Isaksson-Galbraith and Alyssa Haston, from West Calder High School who shared the role of the United Nations Secretariat (top).
Speaking in their role as UN Secretary Generals, they had a message for world leaders ahead of COP30 in Brazil:“Today in Edinburgh, we’ve experienced firsthand how difficult climate negotiations can be, but also how essential they are. We’ve learned that every country has different challenges, but we all share the same planet and the same future.
“The decisions being made at COP30 will shape our lives, our communities, and our world. We urge world leaders to listen to youth voices, to act with urgency, and to remember that compromise doesn’t mean giving up on ambition.
“The climate crisis affects us all, but it doesn’t affect us equally. We must ensure that those most vulnerable are heard and supported. From Scotland to Brazil, young people are ready to lead, but we need action now.”
Did they reach a consensus?
The challenge was to negotiate between countries to keep warming under 2°C by the end of the century, and to aim for under 1.5°C. By the end of the debate, pupils collectively agreed to keep global warming at 1.6°C, just over the mark of the Paris Agreement target. This means they were over the target, but made headway with strategies to reduce greenhouse gas emissions, support nations, and develop adaptation measures to protect cities and people.
The debate simulation was led by climate expert Professor Pete Higgins, Chair in Outdoor, Environmental and Sustainability Education at the University of Edinburgh.
Speaking at the event, Professor Pete Higgins said:“Today’s debate couldn’t be more timely. We’re living through a period of significant political uncertainty, which makes climate diplomacy more complex than ever.
“What impressed me most was how quickly these young people grasped the competing priorities and difficult trade-offs involved, whilst maintaining their determination to find common ground.
“Young people often feel powerless when it comes to climate change, but events like this show that they have both the understanding and the diplomatic skills to navigate these challenges. My hope is that the negotiators at COP30 will show the same wisdom and commitment to meaningful action that these young citizens have demonstrated today.”
Claire de Braekeleer, Director British Council Scotlandadded: “This UN debate simulation puts young people in Scotland at the heart of the global climate debate.
“As COP30 starts in Belém next week, these pupils are gaining crucial insights into how these climate negotiations work. They are also building the diplomatic skills and understanding that will be vital for the international cooperation we desperately need.
“We believe that young people are the key to driving positive climate action, and today demonstrates how collaborating globally with empathy and understanding is the way forward.”
The simulation was part of the British Council’s Schools Connect programme, which aims to bring international perspectives into the curriculum. Students engaged in realistic debates, negotiated complex agreements, and balanced competing interests of nations.
Through the Climate Connection programme, the British Council is also supporting people globally to find creative solutions to climate change in support of the 30th United Nations Climate Change Conference (COP30) in Belém, Brazil.
The British Council is supporting the summit by engaging with networks of education professionals, students, academics, researchers, artists, civil society leaders and policymakers to participate in meaningful dialogue and bring about real change for our planet.
This initiative continues the work of the British Council’s Schools Connect programme for schools in the UK and around the world, building connection, understanding and trust between people in the UK and overseas through arts, education and English language teaching.
For more information about the British Council’s work in Scotland, visit:
Are you part of a local group in Edinburgh, the Lothians, Borders or Fife? Our Community Grants Scheme is available to help bring your ideas to life. Applications are open until Friday 31 October.
View details on how to apply and sign up for our information session: https://edin.ac/489uqJU
Since the scheme began in 2017, we’ve awarded over £822,000 across 330 projects, supporting 252 local organisations to create change that matters to them.
Here’s what that looks like in action:
• Archaeology Scotland brought together 130 local residents for The Big Dig Dalkeith community archaeology project at Newbattle Abbey.
• Leith Sea Cadets replaced old training equipment, boosting confidence and belonging among young people.
• Craigsfarm Community Development Project supported 54 adults with mental health challenges through creative art sessions.
These grants are part of how we deliver on our new Community Plan 2025–30, launching soon. A plan shaped by your voices and built on shared goals for thriving, equal, connected communities.
The Edinburgh Union will host its second debate on Monday (6 October), with a panel of politicians and medical experts debating the motion: This House Welcomes the Legalisation of Assisted Dying.
The debate will feature Kenneth Gibson MSP representing the case for assisted dying. He will be opposite Dr Fiona MacCormick, the Scotland Representative for the Association for Palliative Medicine of Great Britain and Ireland (APM) and Dr Gordon Macdonald, CEO of Care Not Killing, representing the case against.
Two student speakers will also join the debate, taking opposing sides on the motion and bringing the perspectives of Edinburgh’s student body directly into the discussion.
This second event follows the success of the Edinburgh Union’s first debate on Scottish Independence last month, in which a panel of senior Scottish politicians debated to a full audience. This week’s debate is set to be a similar hit, with all 100 tickets selling out in just 4 hours.
The debate takes place just months after the Scottish assisted dying bill passed its first vote in Holyrood in May this year.
Founded in 2025, the Edinburgh Union, which is part of the Edinburgh Political Union, is the University of Edinburgh’s newest debating society. It seeks to provide an apolitical platform dedicated to open dialogue.
With political and social conversations growing increasingly polarised, the Union’s mission is to develop an environment where ideas can be challenged constructively and where participants from all backgrounds feel empowered to engage in discussion.
This semester, the Union will host fortnightly debates in Edinburgh’s iconic Rainy Hall at New College, bringing together speakers from across the political spectrum. Upcoming motions include This House Regrets Brexit and This House Believes Traditional Masculinity is Damaging to Men and Society.
Each debate will offer audience members, comprising students and academics from across Edinburgh with the opportunity to debate and challenge guest speakers from across the political spectrum.
As stated by Founder Finn Tyson:“The Edinburgh Union seeks to spark open dialogue in the capital city of Scotland.
“We want to give students and staff the chance to engage in-person with big ideas, challenge perspectives, and form their own views through reasoned debate – all in a way that reflects the diversity and voice of Scotland’s student population.
“ One of modern Britain’s most profound ethical, legal and personal questions is the legalisation of assisted dying. Despite fierce opposition Scotland, England and Wales stand on the brink of legalisation. This highly controversial issue is rooted in decades of public discourse, poignant personal stories, and evolving legislative efforts.
