Frame Running gives people with MS the freedom to exercise

Researchers at Queen Margaret University (QMU), Edinburgh have found that Frame Running, an adapted form of physical activity, could offer a safe new way for people with advanced Multiple Sclerosis (MS) to take part in sport and exercise. The results of the study, suggests that Frame Running can help people with walking difficulties stay active in a way that feels both enjoyable and achievable, and which could benefit their health and wellbeing.

Frame Running involves exercise with a purpose-built trike which consists of three wheels and has a saddle and handlebars. The frame is propelled by the athlete’s feet and steered by hands or arms.

Its design offers stability and support while walking or running, which may suit many people with mobility and balance issues, including people living with MS. Frame Running has recently been included as a Para-athletic event in the 2028 Paralympic games in Los Angeles and is increasing in popularity in the UK and worldwide, with local clubs springing up across Scotland in places such as East Lothian, Edinburgh, Dunfermline, Glasgow, Ayrshire, Perthshire and Aberdeen.

The study, funded by the UK MS Society, builds on work by QMU’s Professor Marietta van der Linden, which has explored the potential of Frame Running to support mobility, cardiovascular health and personal confidence in young people with cerebral palsy.

The latest study, now extends that understanding to people living with MS. 

The 12-week research project, which brought participants together for weekly sessions at a local athletics track, offers an encouraging picture. It reveals new possibilities for a group that often encounters significant barriers to physical activity.

Professor Marietta van der Linden, a Human Movement scientist at QMU, said: “People with MS, who experience difficulties walking, often have very few ways to exercise safely outdoors at an intensity that genuinely benefits their health. Frame Running may provide people with these positive health effects, while also offering a sense of speed, freedom and confidence that many thought they had lost.” 

The study, which involved 10 participants, showed that Frame Running enabled most people to reach heart rate levels typically associated with moderate to vigorous exercise. Participants showed strong commitment, attending almost every session, and importantly, no serious safety issues were reported.

Most participants enjoyed the experience so much that they continued attending Frame Running sessions offered by the local athletics club long after the study finished, highlighting its appeal and real-world potential. 

Dr Gary McEwan, Research Fellow at QMU and lead author, added: “Seeing participants reach meaningful exercise intensities was incredibly encouraging.

“These levels of activity are linked to improved fitness, better symptom management and enhanced quality of life – yet they’re rarely accessible to people living with significant disability.” 

CASE STUDY

Helen Isserlis, a former nurse from East Lothian, developed MS almost 30 years ago. With significantly declining mobility, she certainly didn’t expect to be running around a track at 59 years of age.

But she recently stumbled upon Frame Running and its enabled her to take part in intensive exercise for the first time in decades. Her participation in the adapted sport has not only restored her movement, it’s offered a sense of freedom and possibility that she’d thought she’d lost. 

“I can’t hop, skip, jump, and I certainly can’t run. But Frame Running has changed my whole mindset. Instead of focusing on what I can’t do, I look forward to what I can do.”

Helen trains once or twice a week with Team East Lothian at Meadowmill stadium in Prestonpans. 

She said: “It gets your heart rate up, your blood pumping and your legs moving. Afterwards, my hips and legs feel far looser, and my pain is reduced. I can now do intensive bursts of exercise, which would have been impossible before, and I’m working up to a 5k in one go. 

“Frame Running has transformed what is physically possible for me. It’s restored my independence, confidence and joy. It’s made me feel alive again.”

While the study was small and exploratory, the findings mark an important next step in a research journey that has already shown Frame Running to be beneficial for other disability groups.

Caitlin Astbury, Senior Research Communications Manager at the MS Society, said: “Research shows being physically active can improve mobility, muscle strength and mood, and help manage MS symptoms like balance problems and fatigue. But we also know it can be difficult for people with advanced MS to find an exercise routine that works for them.

“This research from QMU provides early but promising evidence that Frame Running could be a safe and enjoyable way for people with mobility difficulties to take part in moderate to intense exercise.

“There are more than 17,000 people living with MS in Scotland, and over 150,000 people in the UK. The condition affects nerves in the brain and spinal cord and impacts how people move, think, and feel. Studies like this help to identify and raise awareness of different types of exercise that people with MS may benefit from. We hope to see more research in this area in the future.”

Dr McEwan concluded: “This study adds to a growing body of evidence showing that Frame Running can transform what is possible for people with mobility impairments.

We would therefore encourage more people with MS and other mobility issues to try Frame Running. We’d also love to see further development of Frame Running groups in the community such as within athletics clubs across Scotland and beyond, so that more people with MS have easy access to the sport, equipment and the joy and camaraderie often associated with being part of a sports club.”

To find out more about the research view the research paper.

Woman running 200 marathons in 200 days for charity brings message of hope and resilience to Edinburgh

Megan Boxall is aiming to become the fastest woman to run the entire coastline of Britain and is raising funds for Samaritans, a charity close to her heart.

Megan, who has been running a marathon almost every day since she set off from Suffolk on the 18th October, made it to Edinburgh on Saturday (11th April).

Since arriving in Scotland on the 19th January, Megan has run the length of the West coast of mainland Scotland, and is now on the home straight having run back down the East coast. She aims to have completed the entirety of the challenge by the 18th May, making her the fastest woman to do so.

In taking on this marathon challenge, Megan combines endurance sport with open conversations about mental health and suicide prevention. Not only has Megan raised £30,000 for the suicide prevention charity, but she is also spreading a message of resilience and hope, as well as raising awareness of mental health and help-seeking in rural and coastal communities.

In 2024, Megan was diagnosed with Multiple Sclerosis and faced struggles with her mental health. She made five calls to Samaritans that year which helped her through some of her most difficult moments.

Megan spoke about how important it was for her to have the live-saving opportunity to talk to a Samaritan about how she felt. She said: “Every 90 minutes someone dies by suicide in the UK.

“Samaritans is an amazing charity which is helping to prevent that number from becoming much higher. Its volunteers pick up the phone to someone in need once every ten seconds.

“In 2024, I made five calls to the charity (116 123). Their volunteers were there for me when the pain in my brain was so intense I couldn’t pick myself up off the floor.

“I only wish I had picked up the phone to them sooner.”

Megan follows in her late uncle’s footsteps, who walked the route aged 33 after being diagnosed with Parkinson’s Disease.

Running 200 marathons in 200 days is no mean feat, and a grueling task even in the brightest of weather. The weather in Scotland can offer little encouragement during the early months of the year, but something which has brightened up each daily marathon for Megan has been the people of Scotland that have cheered her on so far.

Megan said: “I have really had some amazing experiences in Scotland so far. Overall, I have been blown away by the Scottish welcome. It really has been so uplifting and what Run Britain is all about.

“I hope that by talking more about my experiences with Samaritans and raising some money while I circle the country, I can help anyone who might be struggling.”

Running and being in nature alongside her dog, adopted from Dog’s Trust in 2022, helped Megan to find a way to cope and carry on. Megan hopes that her run will help raise awareness of Samaritans for anyone struggling with their mental health, as well as the benefits of spending time in nature enjoying the beauty of the coastline.

Megan’s dog, Shadow, accompanies her on some parts of her journey wearing her PitPat GPS tracker to stay safe and track her miles.

Megan started her 5,240-mile (8,433km) journey at Sizewell Beach in Suffolk on the 18th October, and hopes to finish at the same place in May.

Running groups and clubs are invited to join Megan on sections of her journey and can sign-up here. 

You can donate to Megan’s fundraiser through her JustGiving page.

Newly discovered biological process could help repair MS damage

Researchers say previously unidentified feature of myelin could pave the way to new treatment options

Researchers in Edinburgh have discovered that myelin, the protective coating surrounding nerves, which is damaged in multiple sclerosis (MS), could potentially repair itself instead of being lost, thanks to a newly discovered biological response.

This might offer a significant new opportunity to help slow, stop or even prevent degeneration in MS and other conditions like Alzheimer’s disease. 

In MS, the immune system attacks myelin in the brain and spinal cord and disrupts messages being sent around the body. This impacts how people move, think and feel. While myelin loss is a hallmark of a range of conditions, there are still no treatments that can replace damaged or lost myelin.

Until now, research has been focused on regenerating new myelin after it has already been lost. But a team from the MS Society Edinburgh Centre for Myelin Research at the University of Edinburgh, led by Professor David Lyons and supported by international collaborators, has shown that when myelin is first damaged it undergoes a dynamic swelling phase.

This can, in principle, be followed by repair, rather than myelin loss. This potentially offers a window of opportunity to intervene before the myelin completely breaks down. 

Historically, although this myelin swelling had been observed, it had not been investigated in detail, as researchers thought that it might be an artefact of the way brain tissue is preserved in the lab. But this new study took advantage of advanced technology to observe live zebrafish and tissue from mice and humans who lived with MS to follow what happened to damaged myelin over time.

The team showed that this swelling is in fact a natural process in the body that can be followed by repair of the damaged myelin, and thus one that could be a critical step in the body’s fight to prevent complete myelin loss.

This suggests that the nervous system has a powerful – and until now unrecognised – ability to withstand early myelin damage. 

Professor David Lyons, Co-lead of the MS Society Edinburgh Centre for MS Research, at the University of Edinburgh, says: “These findings suggest that intervening during this early swelling phase could protect myelin before it is lost, offering us the opportunity to explore potential new treatment routes that could complement current treatments.

“For decades, scientists have focused on remyelination, the process of rebuilding myelin once it is already lost. This continues to hold promise. But now that we have this new avenue of exploration, it could be the start of something else very special.”

Over 150,000 people in the UK live with MS, with 135 diagnosed each week. More than 17,000 people with MS live in Scotland. The MS Society is the largest charitable funder of MS research in the UK. Its research has helped drive forward treatment options and dramatically improved public understanding of the condition.

The University of Edinburgh is home to one of Europe’s largest groupings of neuroscience researchers investigating the nervous system in health and disease. This includes one of two MS Society-funded Centres of Excellence in MS research.

Work at the Edinburgh Centre for MS Research, co-led by Professor Lyons and Professor Anna Williams, spans investigation of fundamental biological processes relevant to MS, drug discovery to identify treatments for MS, through clinical research and supporting clinical trials in people with disease.

Dr Emma Gray, Director of Research at the MS Society, says: “We know that the body has the ability to regenerate new myelin after it’s lost. But this study shows that existing myelin can sometimes self-heal before it’s fully lost, a process we hadn’t identified before.

“It doesn’t replace current strategies, but it adds another potential way to protect myelin early on. MS can be debilitating, exhausting and unpredictable and for tens of thousands of people there are still no treatments that work for them.

“There’s still a lot to learn, but discoveries like this are essential to help people with MS in the future.”

To read the full research paper visit: 

https://www.science.org/doi/10.1126/science.adr4661