Brits’ favourite ways to spend time with their Grandparents
– Nostalgic conversations are the nation’s favourite way to spend time with their grandparents
– Research reveals top 10 activities include baking, gardening, and playing board games
– Psychotherapist, Andre Radmall, explains why it’s so important for grandchildren to spend time with their grandparents.
Reminiscing about the past (32%) is the nation’s favourite activity to do with their grandparents, new research has revealed.
The study was conducted by Gala Bingo, the nation’s favourite bingo site, to launch its new Paddle Pals TV advert, which celebrates the bond we have with our grandparents.
Playing card games (31%), looking through old photographs (30%) and baking (30%) were some of the other ways in which we cherish time with Grandma and Grandad.
Men and women tend to have different favourites, however, as while talking about history is the favourite grandparent pastime for men, baking takes the top spot for women. Almost two in five (38%) women say baking is their favourite thing to do with their grandparents, compared to just 21% of men. Yet men and women equally enjoy spending time planting and pruning in the garden (26%) with their elders.
Interestingly, age plays a part in which activities are most enjoyed. Cooking alongside their grandparents is a popular activity for both the 25-34 (41%) and the 35-44 (33%) age groups. For the younger generation (18-24), taking the dog for a walk with their grandparents topped the list at 31%.
Overall, the nation’s top 10 favourite activities to do with their grandparents are:
Talking about the past – 32%
Playing cards – 31%
Going through old photos – 30%
Baking – 30%
Cooking – 28%
Playing board games – 28%
Gardening – 26%
Walking – 23%
Going to the park – 23%
Doing puzzles, crosswords, word games –20%
Dog walking (15%), taking a trip to the beach (15%) and puzzling over jigsaws (19%) were among the other wholesome activities that were mentioned but didn’t quite make the top 10.
Sporty activities such as swimming (4%) and bowling (3%) were some of the least popular endeavours.
There is also variation across the UK. Playing board games with the grandparents is the preferred activity for people in Bristol and Edinburgh (both 37%) whereas taking a stroll around a park is the favourite thing to do for those in Liverpool (31%) and Sheffield (33%).
Psychotherapist and author Andre Radmall said: “The relationship between grandparents and their grandchildren is immensely important. Spending time with each other provides innumerable benefits for both.
“Grandchildren can learn from the experience of grandparents, passing on their wisdom through to adulthood which can be a rewarding and meaningful experience for grandchildren.”
Karina Adrian, head of brand marketing at Gala Bingo, said: “It’s really great to see the nations appreciation and love we share for our grandparents.
“There are so many shared experiences between a grandparent and their grandchild, with this research reflecting just how much of a positive impact the bonds with our grandparents can have on us as adults.
“We hope this research has inspired people to spend some quality time with their grandparents this week and reminisce on good times spent with them.”
New research led by Queen’s University Belfast has shown that dogs can predict epileptic seizures, offering a warning sign to owners that has the potential to save lives.
Epileptic seizures are associated with a specific smell which is detectable by pet dogs. The study analysed the reaction of dogs to odours and found that the dogs could predict when a seizure was imminent.
A reliable early warning system to make people with epilepsy aware of an impending seizure has the potential to save lives, reduce injury, provide an opportunity for medical intervention and return a sense of independence to those living with unpredictable seizures.
Epilepsy is a debilitating and potentially life-threatening neurological condition which affects approximately 65 million people worldwide, of whom 30% (20 million), are unable to control their seizures by medication. There is currently no reliable and simple early warning seizure-onset device available, which means many people with unstable epilepsy live in fear of injury or sudden death and the negative impact of social stigmatization.
There have been anecdotal accounts of pet dogs predicting their owner’s epileptic seizures by becoming attentive and by demonstrating attention-seeking behaviours, but to date no scientific study has investigated the veracity of these claims.
Lead researcher Dr Neil Powell (above), from the School of Biological Sciences at Queen’s University Belfast, said: “We hypothesized that, given the extraordinary sense of smell of dogs, a volatile organic compound exhaled by the dog’s epileptic owner may provide an early warning trigger mechanism to which make dogs react before the seizure. The results have shown pet dogs to be a reliable source to detect an on-set seizure.”
The study has been published in the journal MDPI Animals.
The researchers explored how a cohort of pet dogs reacted to the emergence of seizure-associated odours. Using two specially designed pieces of apparatus called the Remote Odour Delivery Mechanism (RODM), the researchers separately delivered epileptic seizure-associated odours and nonseizure associated odours and recorded the reactions of the dogs to each.
Using 19 pet dogs with no experience of epilepsy, the researchers exposed them to odours that were deemed to be characteristic of three seizure phases, by using sweat harvested from people with epilepsy.
By altering the alternating odours emerging from sweat samples, captured before seizure, during a seizure and after a seizure, and two nonseizure controls, the researchers recorded the response of the 19 pet dogs.
They found that all 19 dogs demonstrated more affiliative behavioural changes when confronted by seizure-associated odours, compared with their response to control odours.
Dr Powell added: “Our findings clearly showed that all dogs reacted to the seizure-associated odour whether this was through making eye contact with their owner, touching them, crying or barking. There is a unique volatile smell linked to epiletic seizures, detectable by dogs who can in-turn warn their owner a seizure is likely to occur.
“Our research was based on pet dogs with no prior training. If we can train dogs, this has the potential to make a big difference to owners who experience unpredictable seizures and should go a long way in improving not only their safety, but also their quality of life.”
The research was funded by and conducted in partnership with Epilepsy Ireland and Disability Assistance Dogs.
Peter Murphy, CEO of Epilepsy Ireland, said: “A reliable method of seizure prediction and detection is the holy grail for many people living with epilepsy as well as the parents of children with the condition.
“This is especially the case where seizures involve the loss of consciousness, with a high risk of injury. While recent efforts have focused on technological solutions, it is exciting and very welcome news that anecdotal reports of dogs’ ability to predict seizures have now been backed up by scientific evidence.
“We have been immensely proud to support Dr. Powell’s work and we hope that the findings will lead to new approaches alongside ‘man’s best friend’ that promote safety and offer reassurance for people living with epilepsy.”
An ambitious new research project, Spectrum 10K, launches today and will recruit 10,000 autistic individuals, as well as their relatives, living in the UK.
There is an urgent need to better understand the wellbeing of autistic individuals. Spectrum 10K hopes to answer questions such as why some autistic people have epilepsy or poor mental health outcomes and others do not
Simon Baron-Cohen
Spectrum 10K is led by researchers at the world-leading Autism Research Centre (ARC), the University of Cambridge, together with the Wellcome Sanger Institute and University of California Los Angeles (UCLA) and will study how biological and environmental factors impact on the wellbeing of autistic individuals.
In the UK, there are approximately 700,000 autistic individuals. The level of support needed by autistic individuals varies considerably. Many autistic people have additional physical health conditions such as epilepsy, or mental health conditions such as anxiety or depression.
It is unclear what gives rise to the diversity within the autism spectrum or why some autistic people have better outcomes than others. The project aims to answer this question and to identify what support works best for each individual.
Professor Simon Baron-Cohen, leading Spectrum 10K and Director of the ARC, explained: “There is an urgent need to better understand the wellbeing of autistic individuals. Spectrum 10K hopes to answer questions such as why some autistic people have epilepsy or poor mental health outcomes and others do not.”
Individuals of all ages, genders, ethnicities and intellectual capacities will take part in Spectrum 10K. Eligible participants join by completing an online questionnaire and providing a DNA saliva sample by post.
Autistic participants involved in Spectrum 10K can also invite their biological relatives (autistic or otherwise) to participate.
Information collected from the questionnaire and DNA saliva sample, and information from health records will be used to increase knowledge and understanding of wellbeing in autism.
Dr James Cusack, CEO of the autism research charity Autistica and an autistic person, said: “We are delighted to support Spectrum 10K. This project enables autistic people to participate in and shape autism research to build a future where support is tailored to every individual’s needs.”
The Spectrum 10K team views autism as an example of neurodiversity and is opposed to eugenics or looking for a cure for preventing or eradicating autism itself. Instead, their research aims to identify types of support and treatment which alleviate unwanted symptoms and co-occurring conditions that cause autistic people distress.
The Spectrum 10K team collaborates with an Advisory Panel consisting of autistic individuals, parents of autistic children, clinicians, and autism charity representatives to ensure Spectrum 10K is designed in a way that best serves the autistic community.
27 specialist NHS sites around the UK are also helping with recruitment for Spectrum 10K.
Dr Venkat Reddy, Consultant Neurodevelopmental Paediatrician in the Community Child Health Services at Cambridgeshire and Peterborough NHS Foundation Trust, said: “There is a need to conduct further research into autism and co-occurring conditions to enable researchers and clinicians to build a better understanding of autism.
“I would encourage autistic individuals and their families to consider taking part in Spectrum 10K.”
Dr Anna and Alastair Gadney, parents of a teenager with autism and learning difficulties: “We have been exploring, over many years, how to implement the best support for our son.
“We wholeheartedly endorse Spectrum 10K and hope our involvement can help increase understanding of autism and in-turn support many families out there.”
Chris Packham, naturalist and TV presenter who is also autistic, said: “I’m honoured to be an ambassador of Spectrum 10K because I believe in the value of science to inform the support services that autistic kids and adults will need.”
Paddy McGuinness, actor, comedian, television presenter, and father of three autistic children, said: “As a parent of three autistic children, I am really excited to support Spectrum 10K.
“This research is important to help us understand what makes every autistic person different, and how best to support them.”
Recruitment for Spectrum 10K is now open. Autistic children under the age of 16 must be registered by their parent or legal guardian. Autistic adults who lack the capacity to consent by themselves must be registered by a carer/or family member.
Low angle view of layered herb plants enjoying hydroponic technology system of controlled LED light and CO2-infused air in pristine growing chamber.
Scotland’s Rural College (SRUC) will be the first higher education institute in Scotland to open a vertical farm for research and education.
It will build the half million-pound facility at its King’s Buildings campus in Edinburgh next year.
The project, which has received a £200,000 grant from the Scottish Government, will be used in key research into plant and crop science and will also be used by students.
The facility will grow nutrient-dense fruit and vegetables that have specific human health qualities. It will also analyse crop yield and growth rates with all resource inputs to compare their carbon footprint to other production systems.
It will operate on renewable energy sources from the national grid, supported by battery technology to manage peaks in energy demand.
With only a handful of commercial vertical farms in Scotland, the facility will be important for demonstration and knowledge exchange with farmers, growers and small businesses, giving vital support and promoting innovation.
Mairi Gougeon, Cabinet Secretary for Rural Affairs and Islands, said: “As we look to produce more fruits and vegetables locally, vertical farming could provide us with a way to make better use of our land.
“It’s an exciting and innovative field that could bring us real benefits and it is important that we have the skills in Scotland to take advantage of this technology.
“By supporting the industry at an early stage, we can assess these benefits and help to focus our long-term strategy. We will also be reaching out to the wider industry to explore in further detail the opportunities low-carbon vertical farming offers. We will work together to establish the future of vertical farming in Scotland.”
Professor Wayne Powell, Principal and Chief Executive of SRUC, said: “One of the most critical challenges we face is how to feed a growing global population. We have been teaching farmers for generations but, as the population increases, it is important that we look at growing different, more nutritious crops to support healthy diets and local access to food.
“Not only will this vertical farming unit be a valuable asset to our students, but it will also provide us with important data to help optimise and promote innovation into this expanding industry.”
The project will be going out to tender in the coming weeks.
This Edinburgh University Dept of Clinical Psychology project aims to evaluate the impact of nature walks for older adults who would otherwise be restricted in their ability to access nature.
The University of Edinburgh are looking for participants who are:
• 65 and over
• Fluent in English
• Unable to access nature based outdoor spaces
Participation involves taking part in an online survey and watching a short video clip. This should take around 40minutes.
New research published today in a leading GP journal shows that large parts of Scotland do not have an effective way of identifying people with liver disease, resulting in late diagnosis.
The research, produced from a survey undertaken by the British Liver Trust, used a Freedom of Information request, and shows for the first time how many areas across the country have little or no formal structures in place for detecting and managing liver disease and liver cancer.
The mapped survey results (see below) also show huge swathes of the UK (marked in red) do not have any effective patient pathway in place. This is in sharp contrast to other chronic conditions such as diabetes and heart disease, where patients receive standardised care.
Figure 1 Areas in red have no pathway in place. Amber denotes areas with a partial pathway or pathway in development. Green areas have a full pathway in place. Areas in black did not respond.
Three quarters of people in the UK are currently diagnosed when it is too late for effective intervention or treatment and one in four people diagnosed late in hospital sadly die within a couple of months.
The charity is now calling for earlier detection of liver disease and better patient care across all regions of the UK to be prioritized, and is working to influence healthcare commissioners.
Dr Helen Jarvis, Clinical Advisor for the British Liver Trust and lead author of the research, says: “Anyone who has liver disease, or is at risk of getting it, should get the medical care and advice they need no matter where in the country they live.
“The publication of this new data shows that, unfortunately, in the UK this is not yet the case. There are pockets of good practice, but there are also many areas that do not have a consistent approach to testing for and diagnosing liver disease. It shouldn’t be a postcode lottery.
“GPs and other healthcare professionals in primary care are doing a fantastic job under a lot of pressure, but in many areas, they’re working within a system that doesn’t allow them to detect and treat liver disease effectively.
“Unfortunately, many GPs also report a lack confidence and knowledge when it comes to managing the condition. Sadly, this means that in many cases, people with liver disease are diagnosed far too late when treatment options are limited. This had led to thousands of avoidable deaths.
“The liver is an incredibly resilient organ, but only up to a point. Symptoms of liver disease often only appear once damage has progressed and the liver is starting to fail. However, 90% of liver disease is preventable and, in many cases, it’s reversable if caught in time. That’s why early detection and prevention are key.”
Pamela Healy OBE, Chief Executive of the British Liver Trust, said: “Shockingly, deaths due to liver disease have more than doubled in the last 20 years and the condition is expected to overtake heart disease as the biggest cause of premature death in the UK in the next few years.
“Obesity, alcohol and viral hepatitis are the three main risk factors for preventable liver disease.
“We need to take urgent action to stop this silent killer in its tracks. Although the results of our research are very concerning, we do know that there are areas of good practice and that the changes we’re calling for are entirely possible and will save many lives.
“We now need to take what’s working well in those areas with good liver patient care and apply them in others so that every person with liver disease gets the best possible care, no matter where in the UK they live.”
A new study by Queen’s University Belfast and Washington University in St. Louis shows that promoting physical activity is key to achieving the U.N. Sustainable Development Goals (SDG’s).
The research provides new evidence to show that integrating strategies to promote increased physical activity is a key part of the action plan for achieving the United Nations Sustainable Development Goals.
The study found strong links between physical activity promotion strategies and eight out of the 17 SDGs: good health and well-being (SDG 3); gender equity (SDG 5); industry, innovation and infrastructure (SDG 9); reduced inequalities (SDG 10); sustainable cities and communities (SDG 11); climate action (SDG 13); and peace, justice and strong institutions (SDG 16).
Deborah Salvo, Assistant Professor of Public Health at Washington University in St. Louis and lead author on the study, said: “Physical inactivity has been characterized as a pandemic, accounting for 7% of all premature deaths per year globally and resulting in billions of dollars spent on health-related expenditures.”
The international research team applied a modelling method to simulate the effects of large-scale physical activities strategies to gain insights on the potential impacts of widespread scale-up of active transport systems and active urban design strategies on three different city types of high-, middle- and low-income countries.
The simulation results indicated that expected physical activity gains are greater for low- and middle-income countries. In high-income countries with high car dependency, physical activity promotion strategies may help to reduce air pollution and traffic-related deaths, but shifts toward more active forms of travel and recreation and climate change mitigation may require complementary policies that disincentivize driving.
Dr Leandro Garcia, from the Centre for Public Health at Queen’s University Belfast and co-author, said: “The simulation results reveal context-specific relations. In terms of physical activity increases, low- and middle-income country cities stand more to gain from urban transformations that prioritize equitable access to walking, cycling, public transport, and recreational infrastructure.
“As for high-income country cities, findings suggest that to observe meaningful improvements in physical activity levels and climate change mitigation, these types of strategies may need to be further complemented by policies that increase the cost of driving.
“Our research provides strong evidence to illustrate the multiple benefits of promoting physical activity on a large scale, not just for specific areas or populations. The benefits are huge for individuals, communities and to the planet and goes a long way in contributing to the U.N. sustainable development agenda.
“As well as helping to prevent chronic disease, promoting physical activity at scale can reduce traffic deaths and pollution. It helps to create more equitable societies and reduce climate change.
“Physical activity promotion strategies can bring benefits beyond health and bring us closer to a more equitable, sustainable and environmentally friendly future.”
15 new studies across the UK will expand research into long COVID to support thousands of vulnerable people, backed by nearly £20 million through the NIHR
15 new studies across UK to expand research that will support thousands of vulnerable people
Nearly £20 million for research projects will help improve understanding of long COVID and identify effective treatments
Projects include the largest long COVID trial to date which will involve over 4,500 people
Thousands of people suffering with long COVID will benefit from new research programmes backed by £19.6 million to help better understand the condition, improve diagnosis and find new treatments.
An extensive programme of 15 new research studies, backed by government funding through the National Institute for Health Research (NIHR), will allow researchers across the UK to draw together their expertise from analysing long COVID among those suffering long-term effects and the health and care professionals supporting them.
The latest research shows that although many people make a full recovery following COVID-19, a significant proportion of people continue to experience chronic symptoms for months. These ground breaking studies aim to help those people affected return to their normal lives.
The projects will focus on:
Better understanding the condition and identifying it
Evaluating the effectiveness of different care services
Better integrating specialist, hospital and community services for those suffering with long COVID
Identifying effective treatments, such as drugs, rehabilitation and recovery to treat people suffering from chronic symptoms
Improving home monitoring and self-management of symptoms, including looking at the impact of diet, and
Identifying and understanding the effect of particular symptoms of long COVID, such as breathlessness, reduced ability to exercise and brain fog
Health and Social Care Secretary, Sajid Javid, said: “Long COVID can have serious and debilitating long term effects for thousands of people across the UK which can make daily life extremely challenging.
“This new research is absolutely essential to improve diagnosis and treatments and will be life-changing for those who are battling long-term symptoms of the virus.
“It will build on our existing support with over 80 long COVID assessment services open across England as part of a £100 million expansion of care for those suffering from the condition and over £50 million invested in research to better understand the lasting effects of this condition.”
Professor Nick Lemoine, Chair of NIHR’s long COVID funding committee and Medical Director of the NIHR Clinical Research Network (CRN), said: “This package of research will provide much needed hope to people with long-term health problems after COVID-19, accelerating development of new ways to diagnose and treat long COVID, as well as how to configure healthcare services to provide the absolute best care.
“Together with our earlier round of funding, NIHR has invested millions into research covering the full gamut of causes, mechanisms, diagnosis, treatment and rehabilitation of long COVID.”
The selection process for this broad range of innovative studies into long COVID involved people with lived experience at every stage and their input has been invaluable in shaping the outcome of this call and the research projects which will receive funding.
The projects include:
STIMULATE-ICP at University College London which will be the largest long COVID trial to date, recruiting more than 4,500 people with the condition. With £6.8 million of funding, the project will test the effectiveness of existing drugs to treat long COVID by measuring the effects of 3 months’ treatment, including on people’s symptoms, mental health and outcomes such as returning to work. It will also assess the use of MRI scans to help diagnose potential organ damage, as well as enhanced rehabilitation through an app to track their symptoms.
The immunologic and virologic determinants of long COVID at Cardiff University with nearly £800,000, which will look at the role of the immune system in long-term disease and whether overactive or impaired immune responses could drive long COVID by causing widespread inflammation.
ReDIRECT at University of Glasgow backed by nearly £1 million, which will assess whether a weight management programme can reduce symptoms of long COVID in people who are overweight or obese.
LOCOMOTION at University of Leeds with £3.4 million, which focuses on identifying and promoting the most effective care, from accurate assessments in long COVID clinics to the best advice and treatment in surgeries, as well as home monitoring methods that can show flare-ups of symptoms. The research aims to establish a gold standard of care that can be shared across England and the rest of the UK.
EXPLAIN at University of Oxford backed by £1.8 million, which will seek to diagnose ongoing breathlessness in people with COVID-19 who were not admitted to hospital, using MRI scans to trace inhaled gas moving into and out of the lungs to assess their severity and whether they improve over time.
UK Government Minister for Scotland Iain Stewart said: “Long Covid is a terrible illness affecting thousands of people across the UK, and as it’s such a new disease, there’s still a lot we don’t know about it.
“This UK Government funding, which is supporting studies led by the University of Glasgow and University of the West of Scotland, will help us make progress in understanding long Covid and hopefully improve treatment and support for patients right across the UK.”
Professor Amitava Banerjee, Associate Professor in Clinical Data Science and Honorary Consultant Cardiologist, University College London, Chief investigator of the STIMULATE-ICP (Symptoms, trajectory, inequalities and management: understanding long COVID to address and transform existing integrated care pathways) trial, said: “Individuals with long COVID have long been asking for recognition, research and rehabilitation.
“In our two-year study across six clinical sites around England, we will be working with patients, health professionals, scientists across different disciplines, as well as industry partners, to test and evaluate a new ‘integrated care’ pathway from diagnosis to rehabilitation, and potential drug treatments in the largest trial to-date.
“We will also be trying to improve inequalities in access to care and investigating how long COVID compares with other long-term conditions in terms of use of healthcare and burden of disease, which will help to plan services.”
Dr Dennis Chan, Principal Research Fellow, Institute of Cognitive Neuroscience, University College London, Chief investigator of the CICERO (Cognitive Impairment in long COVID: PhEnotyping and RehabilitatiOn) project, said: “Cognitive impairment, referred to informally as ‘brain fog’, is a major component of long COVID that compromises people’s daily activities and ability to return to work.
“The aim of this study is twofold; first, to understand better the nature of this ‘cognitive COVID’ in terms of the cognitive functions affected and the associated brain imaging changes, and second, to test whether neuropsychological rehabilitation can improve people’s outcomes.
“If this study is successful we will not only understand much better the way in which COVID affects the brain but also provide NHS services with new tools to help people recover from their cognitive difficulties.
Professor Fergus Gleeson, Professor of Radiology and Consultant Radiologist, Oxford University, Chief Investigator of EXPLAIN (HypErpolarised Xenon Magnetic Resonance PuLmonary Imaging in PAtIeNts with Long-COVID) project, said: “Following on from our earlier work using hyperpolarised xenon MRI in patients following hospitalisation with COVID-19 pneumonia, where we showed that their lungs may be damaged even when all other tests were normal, it is critical to determine how many patients with long COVID and breathlessness have damaged lungs, and if and how long it takes for their lungs to recover.
“Hyperpolarised xenon MRI is a safe scanning test that requires the patient to lie in the MRI scanner and breathe in one litre of the inert gas xenon that has been hyperpolarised so that we can see it using MRI.
“The scan takes a few minutes and does not require radiation exposure, so it may be repeated over time to see lung changes. Using this technique, we can see the xenon – which behaves in a very similar way to oxygen – move from the lungs into the blood stream.
“In this way, we can see if there has been damage to the airways in the lungs, or to the areas where oxygen crosses into the blood stream, which appears to be the area damaged by COVID-19.”
Background information
The projects were funded following a UK-wide research call for ambitious and comprehensive research into understanding and addressing the longer term physical and mental health effects of COVID-19 in non-hospitalised people and will build on the existing research already commissioned to look at long COVID.
In February 2021, 4 projects funded by NIHR and UK Research and Innovation (UKRI) were announced, following the first research call.
The UK began the commissioning of long COVID research in 2020 and some projects are already producing results that are informing the understanding of long COVID. This research call adds to the existing investment of over £30 million of research funding taking the total investment to £50 million.
The National Institute for Clinical Excellence (NICE) has issued official guidance on best practice for recognising, investigating and rehabilitating patients with long COVID. According to NICE guidance, ‘long COVID describes signs and symptoms that continue or develop after acute COVID-19. It includes both ongoing symptomatic COVID-19 (from 4 to 12 weeks) and post-COVID-19 syndrome (12 weeks or more).’
In October 2020, NHS England and Improvement launched a 5 point plan for long COVID. There are now 89 specialist post COVID-19 clinics operating in England.
On 15 June 2021, NHSEI published a new 10 point plan and announced an additional £100 million expansion of care for patients with long COVID.
Study summaries
Developing and testing the best ways to diagnose, treat and provide rehabilitation for people with long COVID
Dr Amitava Bannerjee, University College of London – £6.8m
The wide-ranging symptoms of long COVID are debilitating and need coordinated care from specialists, hospitals and community services. The STIMULATE-ICP (Symptoms, trajectory, inequalities and management: understanding long COVID to address and transform existing integrated care pathways) trial, developed with the help of patient organisations, will be the largest long COVID trial to date, recruiting more than 4,500 people with the condition. This project will test the efficacy of existing drugs to treat long COVID, and measure the different effects of three months’ treatment on patients with regards to their symptoms, mental health and outcomes such as returning to work. It will also assess the use of MRI scans to help diagnose potential organ damage in those recovering from the coronavirus, as well as enhanced rehabilitation – the provision of joined-up specialist care centred around an app for patients allowing them to track their symptoms.
Optimising standards of care for long COVID in hospitals, doctors’ surgeries and at home
Dr Manoj Sivan, University of Leeds – £3.4m
Although there are 83 long COVID clinics in England, most people have not had access to them, and face long waiting times to be seen. The LOCOMOTION (long COVID multidisciplinary consortium: optimising treatments and services across the NHS) project focuses on identifying and promoting the most effective care, ranging from accurate assessments in these clinics to the best advice and treatment in surgeries, as well as home monitoring methods that can show flare-ups of symptoms. Drawing from the experiences of current long COVID patients and NHS professionals, the research aims to establish a ‘gold standard’ of care that can be shared across England and the rest of the UK. Analysis will be conducted in 10 long COVID clinics, at home and in doctors’ surgeries, and the study will track referrals and evaluate different services through patient interviews to make sure they are efficient, accessible and cost-effective. Specialists in healthcare inequality will also ensure that views are sought and recorded from people who are not visiting clinics.
Explaining why long COVID patients experience breathlessness and a reduced ability to exercise
Professor Fergus Gleeson, University of Oxford – £1.8m
One of the most prevalent and persistent symptoms among long COVID patients has been discomfort in breathing following physical activity. The EXPLAIN (Hyperpolarised xenon magnetic resonance pulmonary imaging in patients with Long-COVID) project will seek to diagnose ongoing breathlessness in coronavirus patients who were not admitted to hospital, using MRI scans to trace inhaled gas moving into and out of the lungs.
A 15-minute scan using low levels of xenon gas will display lung function and – if abnormalities are found – comparisons of data across different groups of participants recruited from Oxford and Sheffield can help assess their severity and whether they improve over time. Some EXPLAIN patients will also have a separate scan to see if heart damage can be identified. If the MRI scans separate patients with and without lung disease, further CT scans can be analysed, using artificial intelligence and blood samples to identify associated conditions and inform the development of treatments.
Understanding and treating ‘brain fog’
Dr Dennis Chan, University College London – £1.2m
Up to three quarters of people who experience long-term symptoms after COVID-19 report problems with memory, attention or other cognitive functions – symptoms known collectively as ‘brain fog’. The CICERO (Cognitive Impairment in long COVID: PhEnotyping and RehabilitatiOn) project will first determine which elements of brain function are most affected in people with long COVID. The relationship between brain function and other symptoms of long COVID, such as fatigue and anxiety, will be explored, and MRI scanning will be used to identify the affected brain networks. The researchers will then develop and test a new rehabilitation strategy to help people recover from the cognitive aspects of long COVID and return to normal life and working ability. This will support production of a freely available COVID-19 Cognitive Recovery Guide on how best to offer the new rehabilitation approach depending on the patient’s symptoms.
Co-designing personalised self-management for patients at home
Professor Fiona Jones, Kingston University – £1.1m
Long COVID describes more than 200 different symptoms that can interact and fluctuate. Although fatigue and problems with brain function are the most common symptoms, each patient can experience a different set of symptoms. The LISTEN (Long COVID Personalised Self-managemenT support – co-design and EvaluatioN) project will work in partnership with people who have long COVID to design and evaluate a package of self-management support that can be personalised to individual needs. The researchers will first work with people living with or recovered from long COVID, plus a social enterprise with expertise in reaching seldom heard populations, to design the package and associated patient and training resources. The team will then test the self-management package alongside up to six one-to-one virtual coaching sessions from trained rehabilitation practitioners, to test whether the treatment improves how people with long COVID feel and how they cope with everyday activities. The researchers will also evaluate how the package could be implemented more widely, with the aim that self-management for people with long COVID can be delivered at scale.
ReDIRECT: Remote Diet Intervention to Reduce long Covid symptoms Trial
Dr David Blane, University of Glasgow – £999,679
The immunologic and virologic determinants of long COVID
Professor David Price, Cardiff University – £774,457
Quality-of-life in patients with long COVID: harnessing the scale of big data to quantify the health and economic costs
Dr Rosalind Eggo, London School of Hygiene and Tropical Medicine – £674,679
Percutaneous Auricular Nerve Stimulation for Treating Post-COVID Fatigue (PAuSing-Post-COVID Fatigue)
Dr Mark Baker, Newcastle University – £640,180
Immune analysis of long COVID to inform rational choices in diagnostic testing and therapeutics
Professor Daniel Altmann, Imperial College – £573,769
Understanding and using family experiences of managing long COVID to support self care and timely access to services
Professor Sue Ziebland, University of Oxford – £557,674
Development of a robust T cell assay to retrospectively diagnose SARS-CoV-2 infection and IFN-γ release assay as diagnostic and monitoring assay in Long COVID patients
Dr Mark Wills, University of Cambridge – £372,864
Using Activity Tracking and Just-In-Time Messaging to Improve Adaptive Pacing: A Pragmatic Randomised Control Trial
Professor Nicholas Sculthorpe, University of the West of Scotland – £317,416
Impact of COVID-19 vaccination on preventing long COVID: a population-based cohort study using linked NHS data
Professor Daniel Prieto-Alhambra, University of Oxford – £224,344
Long COVID Core Outcome Set (LC-COS) project
Dr Tim Nicholson, King’s College London – £139,619
An international group of scientists have discovered 13 DNA sequences that are associated with people developing the most severe form of Covid-19.
The identification of the sequences – known as genetic markers – could provide targets for future therapies using repurposed drugs, experts say.
Researchers from the University of Edinburgh joined a global effort to compare the genetic information of almost 50,000 Covid-19 patients with samples provided by healthy volunteers from biobanks, clinical studies, and direct-to-consumer genetic companies like 23andMe.
The team found key differences in 13 genetic markers of Covid-19 patients compared with healthy volunteers. The genes partially explain why some people become seriously ill with Covid-19, while others are not affected.
By pooling the large amount of data from 25 countries, the scientists were able to produce robust analyses more quickly, and from a greater diversity of populations, than any one group could have on its own.
The team also identified factors such as smoking and high body mass index as reasons why some people suffer from Covid-19 more acutely.
Of the 13 genetic markers identified so far, two occur more often among patients of East Asian or South Asian ancestry than in those of European ancestry.
One of these two markers, near the FOXP4 gene, is linked to lung cancer. The different FOXP4 sequence associated with severe Covid-19 increases the gene’s expression, suggesting that inhibiting the gene could be a potential treatment strategy, experts say.
Other genetic markers associated with severe Covid-19 included DPP9, a gene also involved in lung cancer and pulmonary fibrosis, and the TYK2 gene, which is implicated in some autoimmune diseases.
The latest findings come from the COVID-19 Host Genomics Initiative, which have been published in Nature.
The initiative has grown to be one of the most extensive collaborations in human genetics and currently includes more than 3,300 researchers and 61 studies from 25 countries.
The University of Edinburgh led study GenOMICC (Genetics of Susceptibility and Mortality in Critical Care) is one such project that contributed data to the COVID-19 Host Genomics Initiative.
GenOMICC started in 2015 as an open, global consortium of intensive care clinicians dedicated to understanding genetic factors that influence outcomes in intensive care from diseases such as SARS, influenza and sepsis.
Throughout the pandemic it has been focused on Covid-19 research in partnership with Genomics England.
Researchers will continue to identify additional gene regions associated with infection and severe disease, and will begin to study what factors lead symptoms persisting in some patients for months.
GenOMICC is funded by the charity Sepsis Research FEAT, the Intensive Care Society, Wellcome, UK Research and Innovation, Scotland’s Chief Scientist Office, the Department of Health and Social Care and the National Institute for Health Research.
Dr Kenneth Baillie, GenOMICC’s chief investigator and Academic Consultant in Critical Care Medicine and Senior Research Fellow at University of Edinburgh’s Roslin Institute, said: “By working together across the whole world, we are able to accelerate discovery for the benefit of patients.
“This new international analysis builds on the colossal effort made by patients and intensive care research teams across the whole UK in the GenOMICC study.”
New research published by the TUC (produced by Landman Economics) finds that over a million children of key workers are currently living in poverty.
The research, which used the government definition for key workers, found that in some regions more than a quarter of children in key worker households are living in poverty.
Key worker families in the North East have the highest rate of child poverty (29%), followed by London (27%), the West Midlands (25%) and Yorkshire and the Humber (25%).
Government policies could worsen key worker poverty
The TUC says the main reasons for key worker family poverty are low pay and insecure hours – factors that often coincide in occupations such as care workers, delivery drivers or supermarket staff.
High housing costs further reduce keyworker family budgets for essentials like groceries and utility bills. And support through Universal Credit is not enough to guarantee families avoid poverty.
Current government policies are likely to increase child poverty rates. Ministers have capped pay rises for key workers in the public sector, which in some cases will mean real wage losses. And the chancellor is planning to cut Universal Credit for low-income families by £20 per week in October.
The TUC warns that these policies will put the brakes on the nation’s economic recovery by curbing household spending. This will restrain business activity, and impact on wage growth for other workers across the economy.
TUC General Secretary Frances O’Grady said:“Every key worker deserves a decent standard of living for their family. But too often their hard work is not paying off like it should. And they struggle to keep up with the basic costs of family life.
“The prime minister has promised to ‘build back fairer’. He should start with our key workers. They put themselves in harm’s way to keep the country going through the pandemic. Now, we must be there for them too.
“This isn’t just about doing right thing by key workers. If we put more money in the pockets of working families, their spending will help our businesses and high streets recover. It’s the fuel in the tank that our economy needs.”
Support needed for key worker families
The TUC is calling on the government to guarantee decent living standards for key worker families by:
Raising the national minimum wage to £10 per hour immediately.
Ending the freeze on public service workers’ pay and give all public service workers a decent pay rise.
Funding the public sector so that all outsourced workers are paid at least the real Living Wage and get parity with directly employed staff.
Canceling the £20 cut to Universal Credit, which is set to hit low-income families in October, and set out plans to increase child benefit above inflation each year across the parliament.
– Children in poverty in key worker households by UK nation and region
Region
Children in poverty in key worker families
Proportion of children in poverty in key worker families
