Tag: diabetic retinopathy

Scottish researchers investigate new treatment for diabetes to combat sight loss

Researchers in Scotland are investigating a new treatment for diabetes which they hope could reduce one of the most common complications of the condition – sight loss.

The team of scientists, funded by the British Heart Foundation (BHF), are aiming to find new ways of preventing diabetic retinopathy (DR) and have been given a grant of £286,000 for the study, which is being led by Professor Mirela Delibegovic in collaboration with clinical colleagues Professor John Forrester and Dr Lucia Kuffova at the University of Aberdeen.

People living with cardiovascular disease and high blood pressure can develop a condition called retinal microvascular disease and this is increased in the presence of diabetes.

Diabetic retinopathy is one of the most common complications of diabetes. Those with DR develop damage, often permanent, to the retina – the light-sensing layer inside the eyeball – and as a result, are at risk of losing their sight.

People in the UK known to have diabetes are offered retinal screening once a year to detect signs of changes in the retina caused by DR. This new project aims to identify physical signs of DR when they occur, but before they lead to loss of vision, and to help find treatments to prevent it from developing.

Professor Delibegovic (above), who is the Director of the Aberdeen Cardiovascular Disease Centre at the University of Aberdeen, explains: “Given its nature, DR is a significant and worrying complication of diabetes and so it is important that we understand more about it and find ways to reduce and prevent it.

“In addition, as Type 2 diabetes – the most common type of diabetes – can often go undetected and undiagnosed for many years, up to 40% of people with Type 2 diabetes already have signs of DR when they are first diagnosed with the condition. Being able to intervene sooner could make a real difference for people living with diabetes.”

Over the next 3 years, the team will investigate if inhibition of an enzyme, called PTP1B, will lead to protection against retinal microvascular disease and diabetic retinopathy.

The BHF is the largest independent funder of research into heart and circulatory diseases in Scotland and this project is one of more than 100 research projects currently underway in ten universities across Scotland.

James Jopling, Head of BHF Scotland, said: “This is an important project which could benefit patients living with heart and circulatory disease and diabetes. As such, it is vital we understand more about diabetic retinopathy.

“Research projects like this one in Aberdeen help inform how we treat patients, identify those at particular risk and ultimately find new ways to save and improve lives.”

For more information on the BHF’s life saving research and the work of the BHF visit www.bhf.org.uk

Your sight could be lost if you don’t attend eye-screenings, charity warns diabetics

As the covid crisis hopefully eases, concerns are being focused on the impact of lockdown on other health conditions. With health centres forced to postpone routine screenings last year, there are fears some conditions may have worsened in the absence of early diagnosis and treatment.

During Diabetes Week this week [June 14-20th], the national sight loss charity RNIB Scotland is emphasising it is more important than ever that people with diabetes attend their regular check-up appointments, now that these have resumed.

RNIB director James Adams said: “Diabetic retinopathy, a complication of diabetes, can affect the small blood vessels at the back of the eye and is a major cause of sight loss among working-age adults. But damage to vision can be arrested if detected early enough.

“While it’s possible that diabetes won’t cause any changes to your sight, the most effective thing you can do to prevent this is to go to your retinal screening appointments and eye examinations, where safety measures are in place.”

The message is also being emphasised by NHS Scotland. Dr Mike Gavin, clinical lead for the national Scottish Diabetic Eye Screening Programme said: “We are working hard to see patients for screening, after the service was temporarily paused during the first lockdown in 2020. Patients should always attend screening whenever they are invited to prevent avoidable loss of sight.”

Each year, 5,500 patients with diabetes in Scotland need to undergo further imaging or see an NHS eye specialist for the first time due to worsening in their retinopathy.

There are 3.5 million people in the UK who have been diagnosed diabetes, and an estimated 500,000 people living with undiagnosed diabetes. Within 20 years of diagnosis, nearly all people with type 1 diabetes and almost two-thirds of people with type 2 diabetes will have developed some form of diabetic retinopathy. People with diabetes are also at increased risk of glaucoma and cataracts.

People from a South Asian or African-Caribbean background are two to four times more likely to get type 2 diabetes. They tend to develop it at a younger age which means they live with the condition for longer.

The risk of complications increases with the length of time people have the condition. It is not known why this is the case, but it is likely to be a mixture of genetics, lifestyle, and environmental factors.

RNIB Scotland is on the steering committee of a five-year study that is following 1,100 retinopathy patients from across Scotland.

The LENS (Lowering Events in Non-proliferative retinopathy in Scotland) trial is testing whether a cholesterol-lowering medicine, fenofibrate, can slow the progression of retinopathy.

LENS is being co-ordinated by the Universities of Oxford and Glasgow in partnership with Aberdeen, Dundee and Edinburgh, and with NHS Scotland’s Retinal Screening Service. More information about the trial is available at: www.ctsu.ox.ac.uk/lens.

* If you’re worried about your vision, contact RNIB’s Sight Loss Advice Service on 0303 123 9999 or visit www.rnib.org.uk/eyehealth. 

For more information on the NHS Scotland eye-screening service, visit  https://www.nhsinform.scot/illnesses-and-conditions/diabetes/diabetic-retinopathy.