Tag: vaccination

Public encouraged to register for COVID-19 vaccine trials

Over 100,000 people have signed up for future COVID-19 vaccine clinical trials through the NHS COVID-19 vaccine research registry of volunteers are helping speed up efforts to find a safe and effective vaccine in the fight against coronavirus

UK researchers urge more volunteers across all groups to sign-up, especially the over 65s and those from Black, Asian and minority ethnic backgrounds

Over 100,000 people have volunteered to take part in COVID-19 vaccine trials, helping to speed up efforts to discover a safe and effective vaccine.

The UK Government is today (Monday 17 August) encouraging more people to join the thousands of volunteers and sign up to the NHS COVID-19 Vaccine Research Registry to help the NHS in the fight against coronavirus and ensure potential candidates work for everyone.

To enable large-scale vaccine studies to take place across the UK, the aim is to get as many people as possible signed up to the Registry by October.

Researchers particularly welcome people from all parts of society, especially those who are more likely to benefit from a vaccine, including the over 65s, frontline health and social care workers, and those from Black, Asian and Minority Ethnic backgrounds.

Clinical studies with a diverse pool of volunteers will help scientists and researchers better understand the effectiveness of each vaccine candidate and will considerably speed up efforts to discover a safe and workable vaccine.

Business Secretary Alok Sharma said: “From John O’Groats to Land’s End, everyone has played their part in tackling coronavirus from wearing face coverings to following social distancing guidance.

“Scientists and researchers are working day and night to find a vaccine that meets the UK’s rigorous regulatory and safety standards, but they need hundreds of thousands of people of all backgrounds and ages to sign-up for studies to speed up this vital research.

“I urge everyone to play our part in the fight against coronavirus and join the 100,000 people who have already registered, so we can help save and protect millions of lives.”

Chair of the government’s Vaccines Taskforce Kate Bingham said: “Protecting those at risk is the only way we will end this pandemic. That’s why we are working as quickly as possible to run clinical studies on the most promising vaccines to see whether they offer protection against COVID-19, whilst adhering to the UK’s strict safety and regulatory processes. And we need people throughout the UK to sign up to the registry to help us achieve this.

“Getting 100,000 volunteers on board is a great start but we need many more people from many different backgrounds that we can call on for future studies if we are to find a vaccine quickly to protect those who need it against coronavirus.”

Consultant Respiratory Physician and Director of the National Institute for Health Research (NIHR) PRC, Bradford, Dinesh Saralaya said: “The best way to protect us from future outbreaks is to develop effective vaccines. Several vaccine trials are being conducted around the UK in the coming months and it is important that we all sign up to be contacted about them.

“I would like to reassure people that research trials and studies are strictly regulated for ethics and safety. They are conducted within the framework of the NIHR, which is the research partner of the NHS, and we take every precaution to safeguard participants taking part. This includes appointments in settings like sports halls close to where people live and work rather than in hospitals.

“By working together, we can produce efficient vaccines which are likely to protect all sections of our society from this dreadful virus in future.”

18-year-old Marium Zumeer from Bradford, who was hospitalised after contracting COVID-19, has first-hand experience of the benefits of taking part in clinical trials.

During her time in intensive care, she was offered the opportunity to take part in the national RECOVERY trial, which is testing a range of potential treatments for COVID-19. This includes the drug dexamethasone, which was found to be the first drug to be effective when treating those who are critically ill with the virus.

RECOVERY trial volunteer Marium Zumeer said: “I will always be grateful for being encouraged to sign up. I remember my dad at the time urging me to take part, not just for myself but for the wider community.

“The result has been really positive for me and I would encourage others to do their bit in helping us all in the fight against coronavirus.

Chief Medical Officer Professor Chris Whitty said: “I’m very grateful to those who have volunteered for researchers to contact them to take part in COVID-19 vaccine studies, via the NHS COVID-19 vaccine research registry. The more people who volunteer to take part the more likely we find an answer to whether any vaccine is effective.

“Having 100,000 volunteers in just four weeks shows the selflessness of the public and is testament to the speed of work done by the Vaccines Taskforce, National Institute for Health Research and others to make signing up possible.

“I urge people to continue to sign up. It is important that we have people from different backgrounds and ages as volunteers, so that the vaccines that are developed work for everyone.”

A number of trials in the UK are expected to begin this autumn, working with the NHS, research institutions and businesses, helping to develop and manufacture the vaccines.

Launched on 20 July, the NHS COVID-19 Vaccine Research Registry is an online service allowing members of the public to register their interest in COVID-19 vaccine studies and be contacted to participate in future clinical trials.

Vaccines are tested in stages to ensure they are safe and effective. Volunteers who are contacted to take part in trials will be given information about what stage a particular vaccine is at and details of how it has already been tested. They will be able to consider this when deciding to take part and people can withdraw from the registry at any point.

The Registry has been developed by the government, in partnership with the NIHR, NHS Digital, the Scottish and Welsh governments and the Northern Ireland Executive.

At least 80 million children at risk as COVID-19 disrupts routine vaccination effort

Measles in India
A newborn receives a routine vaccination at an immunization site, in Ghaziabad, Uttar Pradesh India.

COVID 19 is disrupting life-saving immunization services around the world, putting millions of children – in rich and poor countries alike – at risk of diseases like diphtheria, measles and polio.

This stark warning comes from the World Health Organization, UNICEF and Gavi, the Vaccine Alliance ahead of the Global Vaccine Summit on 4 June, at which world leaders will come together to help maintain immunization programmes and mitigate the impact of the pandemic in lower-income countries.

According to data collected by the World Health Organization, UNICEF, Gavi and the Sabin Vaccine Institute, provision of routine immunization services is substantially hindered in at least 68 countries and is likely to affect approximately 80 million children under the age of 1 living in these countries.

Since March 2020, routine childhood immunization services have been disrupted on a global scale that may be unprecedented since the inception of expanded programs on immunization (EPI) in the 1970s. More than half (53%) of the 129 countries where data were available reported moderate-to-severe disruptions, or a total suspension of vaccination services during March-April 2020.

“Immunization is one of the most powerful and fundamental disease prevention tools in the history of public health,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General.

“Disruption to immunization programmes from the COVID-19 pandemic threatens to unwind decades of progress against vaccine-preventable diseases like measles.

“At the 4 June Global Vaccine Summit in London, donors will pledge their support to Gavi, the Vaccine Alliance, to sustain and accelerate this lifesaving work in some of the most vulnerable countries. From the bottom of my heart, I urge donors to fully fund the Alliance. These countries, these children especially, need vaccines, and they need Gavi.”

The reasons for disrupted services vary. Some parents are reluctant to leave home because of restrictions on movement, lack of information or because they fear infection with the COVID-19 virus. And many health workers are unavailable because of restrictions on travel, or redeployment to COVID response duties, as well as a lack of protective equipment.

“More children in more countries are now protected against more vaccine-preventable diseases than at any point in history,” said Dr. Seth Berkley, Gavi CEO.

“Due to COVID-19 this immense progress is now under threat, risking the resurgence of diseases like measles and polio. Not only will maintaining immunization programmes prevent more outbreaks, it will also ensure we have the infrastructure we need to roll out an eventual COVID-19 vaccine on a global scale.”

Transport delays of vaccines are exacerbating the situation. UNICEF has reported a substantial delay in planned vaccine deliveries due to the lockdown measures and the ensuing decline in commercial flights and limited availability of charters.

To help mitigate this, UNICEF is appealing to governments, the private sector, the airline industry, and others, to free up freight space at an affordable cost for these life-saving vaccines. Gavi recently signed an agreement with UNICEF to provide advance funding to cover increased freight costs for delivery of vaccines, in light of the reduced number of commercial flights available for transport.

“We cannot let our fight against one disease come at the expense of long-term progress in our fight against other diseases,” said Henrietta Fore, UNICEF Executive Director.

“We have effective vaccines against measles, polio and cholera. While circumstances may require us to temporarily pause some immunization efforts, these immunizations must restart as soon as possible, or we risk exchanging one deadly outbreak for another.”

Next week, WHO will issue new advice to countries on maintaining essential services during the pandemic, including recommendations on how to provide immunizations safely.

Mass immunization campaigns temporarily disrupted

Many countries have temporarily and justifiably suspended preventive mass vaccination campaigns against diseases like cholera, measles, meningitis, polio, tetanus, typhoid and yellow fever, due to risk of transmission and the need to maintain physical distancing during the early stages of the COVID-19 pandemic.

Measles and polio vaccination campaigns, in particular, have been badly hit, with measles campaigns suspended in 27 countries and polio campaigns put on hold in 38 countries.

At least 24 million people in 21 Gavi-supported lower-income countries are at risk of missing out on vaccines against polio, measles, typhoid, yellow fever, cholera, rotavirus, HPV, meningitis A and rubella due to postponed campaigns and introductions of new vaccines.

In late March, concerned that mass gatherings for vaccination campaigns would enflame transmission of COVID-19 WHO recommended countries to temporarily suspend preventive campaigns while assessments of risk, and effective measures for reducing COVID virus transmission were established.

WHO has since monitored the situation and has now issued advice to help countries determine how and when to resume mass vaccination campaigns. The guidance notes that countries will need to make specific risk assessments based on the local dynamics of COVID-19 transmission, the health system capacities, and the public health benefit of conducting preventive and outbreak response vaccination campaigns.

Based on this guidance, and following growing concerns about increasing transmission of polio, the  Global Polio Eradication Initiative (GPEI), is advising countries to start planning for the safe resumption of polio vaccination campaigns, especially in polio high-risk countries.

Despite the challenges, several countries are making special efforts to continue immunization. Uganda is ensuring that immunization services continue along with other essential health services, even funding transportation to ensure outreach activities. And in Lao PDR, despite a national lockdown imposed in March, routine immunization in fixed sites continued with physical distancing measures in place.

Pictures: WHO

Free vaccination is best protection against flu

The Health Secretary and Chief Medical Officer have joined to urge all eligible adults to take up the offer of the free flu vaccination. Latest figures from Health Protection Scotland show just over 41% of those aged under 65, who are considered ‘at risk’, have had their flu jab this winter – but cases of flu have more than doubled compared to the same time last year. Continue reading Free vaccination is best protection against flu

Babies will receive Meningitis B vaccine ‘as quickly as possible’

Vaccine to be part of Scottish childhood immunisation programme

baby1

All infants in the UK are to be offered a vaccination against meningitis B following a deal struck between the Westminster government and drug manufacturing giant GlaxoSmithKline. The agreement was also reached on behalf of the Scottish Government and Scotland’s health secretary Shona Robison  said the vaccine will be offered here ‘as quickly as possible’.

The NHS will now introduce the vaccine, Bexsero, to the immunisation programme for infants. Vaccination will prevent the life-threatening strain of meningitis to all infants – around 1,200 people, mainly babies and children, get meningitis caused by the meningococcal group B bacteria each year in the UK, with around one in 10 dying from the infection.

The vaccination will be given in three doses at two, four and 12 months, with all babies in Scotland aged two months at the point of introduction being eligible. The Joint Committee on Vaccination and Immunisation (JCVI) has also advised that when the programme starts there should be a one-off, catch-up programme for babies aged three and four months of age.

Health Secretary Shona Robison said: “The Scottish Government has been consistent in its support for the introduction of the Meningitis B vaccine, Bexsero. We will now work to roll out the vaccination programme as quickly as possible.

“The Meningitis B vaccine will now form part of the routine childhood immunisation programme in Scotland, underlining our commitment to ensuring the health and wellbeing of our children.

“Meningitis B is life-threatening and can affect people of any age, but is most common in babies and young children. By offering this vaccine as part of the routine programme we will be able prevent this and save lives. This disease can be devastating for children and their families and I’m very pleased we can now take the necessary steps to tackle its effects.”