Race Against Time: search is on for coronavirus treatments

The largest randomised clinical trial of potential coronavirus (COVID-19) treatments is underway as part of the race to find a treatment.

The world’s largest randomised clinical trial of potential coronavirus treatments is well underway in the UK as part of the race to find a treatment.

A number of promising treatments are being tested and, if the science supports it, will be given to NHS patients as quickly as possible.

Definitive results on whether the treatments are safe and effective are expected within months and, if positive, they could potentially benefit hundreds of thousands of people worldwide.

Almost 1,000 patients from 132 different hospitals have been already recruited in just 15 days and thousands more are expected to join the Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial in the coming weeks, making it the largest randomised controlled trial of potential COVID-19 treatments in the world.

Health and Social Care Secretary Matt Hancock said: “The coronavirus outbreak is the biggest public health emergency in a generation and we are doing everything we can to fight it on all fronts through our evidence-based action plan.

“The UK is leading the way on research in the race to find treatments and we have now launched the largest trial in the world, pooling resources with our world-leading life science sector.

“As one of three major trials funded by the government, this marks a major milestone in our battle against coronavirus and offers renewed hope that together we can beat this.

“The public still has a crucial role to play by staying at home so we can protect the NHS and save lives.”

The trial is testing a number of medicines recommended by an expert panel advising the Chief Medical Officer for England. They include:

  • Lopinavir-Ritonavir, commonly used to treat HIV
  • Dexamethasone, a type of steroid use in a range of conditions to reduce inflammation
  • Hydroxychloroquine, a treatment for malaria

The trial is being conducted in over 130 NHS hospitals across the UK. Adult patients who have been admitted to hospital with COVID-19 are being invited to take part. The trial is specially designed so that as further medicines are identified, these can be added to the study within days.

Chief Medical Officer Professor Chris Whitty said: “The UK has world-leading life sciences and research sectors and, because of our joined up healthcare and health research system, we have been able to get hundreds of patients involved in this clinical trial in just 2 weeks.

“This marks a significant step in identifying treatments for coronavirus that could benefit patients and underpins our science-backed approach to fighting this virus.”

The trial is being coordinated by researchers at the University of Oxford, led by Peter Horby, Professor of Emerging Infectious Diseases and Global Health in the Nuffield Department of Medicine, and Martin Landray, Professor of Medicine and Epidemiology at the Nuffield Department of Population Health.

To ensure that the healthcare system research resource is directed to benefit the national effort, the National Institute for Health Research (NIHR) has put in place a national process to prioritise COVID-19 research. The RECOVERY trial is one of those prioritised.

The study has received £2.1 million from UK Research and Innovation (UKRI) and the Department of Health and Social Care, through the NIHR. It is part of a wider £20 million rapid research response investment by the government to support looking at ways to tackle the coronavirus outbreak.

The move further bolsters the ‘research’ phase in the government’s science-led coronavirus action plan.

It follows decisive action by the UK’s medicines regulator to fast-track clinical trials for potential coronavirus treatments, meaning NHS patients could have faster access if medicines are proven to be effective.

The Medicines and Healthcare products Regulatory Agency (MHRA) has been working hard to put in place procedures to support manufacturers and researchers developing these treatments and approve clinical trial applications in days, rather than weeks.

Its experience as a world-renowned regulator means these rapid approvals are based on the latest scientific advice and do not compromise the government’s top priority of maintaining patient safety.

Peter Horby, Professor of Emerging Infectious Diseases and Global Health in the Nuffield Department of Medicine, University of Oxford, said: “The RECOVERY trial will provide much-needed evidence on the best care for patients with COVID-19.

“The more patients that are enrolled, the sooner we will know how best to treat this disease.

“We are very grateful to those patients who are participating and to the hospital and research staff who are helping us to find the best treatments.”

Easter childcare for key workers

Learning and childcare hubs for the children of key workers will remain open across Scotland over the Easter holidays.

The move will help support key workers in the NHS and other key sectors on the frontline of the response to coronavirus (COVID-19).

All of Scotland’s local authorities will keep learning and childcare hubs open in their areas to support children and young people. The number of hubs that are open, and the types of support they provide, will vary between each council area in response to local demand.

Education Secretary John Swinney said: “I am very grateful to colleagues in education and childcare who are working so hard to deliver this service.

“Clearly these are unprecedented times and this will be a very different Easter holiday period for teachers and pupils across the country. I would like to thank all of those who have volunteered to provide support over this time.

“Our key workers are on the frontline of the response to coronavirus and it’s only right that we do everything we possibly can to support them.

“By keeping learning and childcare hubs open in our local authorities, we can make sure children are safe and well looked-after while their parents are doing critical jobs helping our communities.”

Guidance on key workers

Key workers whose children already attend learning and childcare hubs will be contacted by their local authority to explain the arrangements over the spring break.

Local authority websites are being updated regularly with the latest information on the learning and childcare hubs and should be contacted directly for further information if necessary.

Stick to advice: STAY HOME THIS WEEKEND

With warm weather forecast this weekend people may feel tempted to head out more, but please stick to government guidance. You are saving lives by staying at home.

Transport Secretary Grant Shapps said: “Don’t travel unless it is essential and particularly avoid using public transport this weekend.

“I know that during the warm weather this weekend people may feel tempted to make the most of it and head out to nearby green spaces more than they have in recent weeks.

“But I want to urge everyone to continue to follow government guidance; that means not travelling too far to exercise or walk pets, staying 2 metres away from other people when outside, and only making journeys when absolutely essential.

“Please remember that anyone can get coronavirus and anyone can spread it – so stay home, protect the NHS, and save lives. As the Prime Minister has said, we will beat coronavirus, and we will beat it together. But to do that we need to stick with the guidance in place, and not break the regulations set to help tackle this outbreak.

“And for those people in the transport sector continuing to work day in and day out to ensure frontline workers can get to work, I want to reiterate my heartfelt thanks at the efforts and dedication you’re showing in helping with this nationwide effort.”

Morrisons thanks staff with threefold increase in bonus for next 12 months

  • Full time colleagues will earn a bonus of £1,050 compared to around £350 average last year
  • The special bonus is the largest for frontline supermarket staff announced in recent weeks

Morrisons is recognising the huge effort by its colleagues who are helping to feed the nation during the coronavirus outbreak by increasing this year’s annual bonus payout threefold from last year.

Morrisons annual colleague bonus will become a ‘thank you’ bonus with the increase lasting for the next 12 months.

Because it will be a percentage of the entire year’s pay, frontline colleagues at Morrisons will see the largest special bonus of those announced over the last few weeks in the supermarket sector.

Morrisons colleagues have worked tirelessly to help meet demand and to thank them they will see these changes to the current bonus scheme:

  • All frontline colleagues will receive a 6% bonus on their earnings for the next 12 months rather than just the next 8-12 weeks
  • The changes represent a bonus payment of £1,050 for a full-time frontline colleague compared to the £351 that would have been paid last year
  • The bonus will be guaranteed in recognition of the effort made by very hard working colleagues
  • It will be paid quarterly so colleagues don’t have to wait until next year to be paid
  • The bonus will continue to be paid as a percentage of actual earnings as per previous years
  • Colleagues who are off sick or are self-isolating will remain eligible
  • Both permanent and temporary colleagues will be eligible in recognition of the thousands of new colleagues who have joined Morrisons in recent weeks.

Clare Grainger, Group People Director said: “Our highly valued colleagues have stood tall amidst the coronavirus pandemic, playing their full part in feeding the nation.

“We want to thank every single one of them for their continued hard work during these unprecedented times by paying a much higher guaranteed bonus for the whole year in recognition of their effort.”

Morrisons frontline salaried managers are also guaranteed to receive a bonus that will be twice their maximum yearly amount in a normal year, again guaranteed and paid quarterly.

The bonus overhaul is the latest change that Morrisons has put in place for its highly valued colleagues.

Previous measures include paying extremely vulnerable and high risk colleagues 12 weeks paid leave to self isolate as well as paying 12 weeks paid leave to colleagues who live with someone who is high risk and extremely vulnerable.

In store, perspex screens have been installed to protect colleagues and customers while paying for groceries at the checkouts and social distancing measures have been introduced.

#ItsMoreThanOurJob

Deliveries begin for high risk groups

People in Scotland at highest risk of severe illness from coronavirus (COVID-19) will begin to receive home deliveries of essential groceries today.

Letters from the Chief Medical Officer have been issuing this week to those who are at greatest risk of COVID-19, to provide bespoke guidance on shielding from infection and information about the support available, which includes access to home deliveries through a text message service.

People who have received the letter this week and signed up to the service have been texted with the option of starting their weekly deliveries of essential food items including soup, pasta, rice, fruit, vegetables, tea, coffee and biscuits, as well as toiletries such as shower gel and toilet roll, on Friday.

Other measures being put in place include:

  • Specialist medicines such as chemotherapy drugs delivered through local health boards
  • Local Resilience Partnerships working with Community Pharmacy to scale up deliveries of pharmacy medicines
  • Work with supermarkets to ensure priority delivery slots for people at high clinical risk

Deputy First Minister John Swinney said: “These new services are available to those at the highest risk of severe illness from COVID-19 who do not have support structures around them to help.

“This includes people with specific forms of cancer, severe respiratory conditions, certain rare diseases, recipients of organ transplants, those on immunosuppression therapies and pregnant women with congenital heart disease.

“Many people will have support from friends and family but I would encourage everyone who receives a letter and requires support to sign up to the service immediately – this will ensure you have adequate supplies of food and essential items during these challenging times.

“It is vitally important that people at highest clinical risk are shielded as much as possible, and our advice alongside this text service will help protect people from the detrimental effects of the virus, including disruption to health and social care and key services.

“Our local services must prioritise those most in need and – by doing so – we will protect them, reduce the burden on the NHS and save lives. By continuing to work together, we can all play our part in keeping everyone safe.” 

Those in the high risk group who do not have access to mobile phones will be able to register for deliveries through their local authority.

Contact details are on the NHS Inform website and can also be accessed through the main switchboard number for local councils.

The grocery delivery service will be led by Brakes and Bidfood with the first deliveries expected on 3 April.

The six categories of risk – as agreed by the UK’s Chief Medical Officers – are:

1. Solid organ transplant recipients

2. People with specific cancers:
a. People with cancer who are undergoing active chemotherapy or radical radiotherapy for lung cancer
b. People with cancers of the blood or bone marrow such as leukaemia, lymphoma or myeloma who are at any stage of treatment
c. People having immunotherapy or other continuing antibody treatments for cancer
d. People having other targeted cancer treatments which can affect the immune system, such as protein kinase inhibitors or PARP inhibitors
e. People who have had bone marrow or stem cell transplants in the last six months, or who are still taking immunosuppression drugs

3. People with severe respiratory conditions including all cystic fibrosis, severe asthma and severe COPD

4. People with rare diseases and inborn errors of metabolism that significantly increase the risk of infections (such as SCID, homozygous sickle cell)

5. People on immunosuppression therapies sufficient to significantly increase risk of infection

6. People who are pregnant with significant congenital heart disease

Initial estimates of the numbers involved were 150,000-200,000, however, a large number of people have been found to qualify in more than one category, and examination of patient records has identified patients who do not fall into the categories and do not need to apply such stringent measures to protect themselves.

NET sends further £5million to front line charities

The National Emergencies Trust has announced a further £5m of funding will be distributed to front line charities today helping those most impacted by the coronavirus outbreak. This is possible thanks to the generosity of the UK public, major charitable trusts and corporate donations.

So far, around half of the £16m total pledged to the Coronavirus Appeal has been given out (£7.5m in total), following an initial allocation of almost £2.5m a week after the appeal launched. Further distributions will be made in the coming days, to continue to support the most vulnerable in society.

The money will be distributed through UK Community Foundations to 46 local community foundations across the country.

Major businesses and charitable trusts across the UK, as well as the British public, have generously donated to the appeal, including corporate donors such as BT, Tesco, HSBC, M&S and National Grid.

The appeal is responding to the needs of local communities across the UK and allocating money to community foundations based on local factors such as levels of deprivation and demographics in each region.

Local Distribution

A snapshot of some of the local groups already benefitting from the appeal include:

Horncastle Food Bank

Horncastle Food Bank in Lincolnshire which has seen a 300% increase in demand for food and hygiene parcels. The group has also stepped in to help combat child poverty, by providing food for those children no longer receiving free school meals and are now also distributing hot meals for vulnerable people currently in isolation.

ASD Helping Hands

ASD Helping Hands helps those caring for children and young adults with autism, supporting over 1,300 families in Norfolk. Since the outbreak, the organisation has launched a web and phone-based advice and listening service to continue to support the mental wellbeing of families during this stressful time.

Musical Memories

Social enterprise Musical Memories saw its 5th anniversary Big Sing concert for more than 150 older people in the community cancelled due to the outbreak. However, the social enterprise hasn’t been deterred and is now hosting live music online sessions every day for older people across rural Yorkshire to help fight loneliness and isolation. Funding will provide recording equipment to facilitate ever more creative and engaging remote concerts.

NET Coronavirus Appeal

The National Emergencies Trust’s Coronavirus Appeal was launched in partnership with the British Red Cross and with the support of the Duke of Cambridge.

Anyone can make a donation and further donations can be made by clicking the below button.

 

This week celebrity supporters including Miranda HartJoe Lycett and Kate Thornton have shared video messages on their social media urging the public to get behind the appeal.

John Herriman, CEO of the National Emergencies Trust, said: “It is fantastic that good causes across the UK are already seeing the benefits of the public’s support and the overwhelming generosity of our corporate donors. It’s vital that we are able to offer support to these groups as soon as we can.

“Our work may have started but there is still much more to do. We’re asking the public to get behind the appeal and make contribution if possible, or to spread the word to help raise awareness.

“Everyone who donates can be confident their money is reaching those in need quickly and making an instant difference to the most vulnerable in our communities at this difficult time. We need to come together more than ever and I’m heartened the British public are rising to the challenge.”

Rosemary Macdonald, Interim CEO of UK Community Foundations, said: “Working closely with our network of 46 community foundations, we’re seeing unprecedented demand for support from those in need across our society.

“We’re working to make sure that donations reach communities quickly and in response to particular needs, so that we are properly supporting the most vulnerable as best we can.”

In Awe of our Carers

SCOTS are being urged to show their appreciation for the work of Scotland’s vast army of social care workers who are continuing to provide vital services to older and vulnerable people during the Coronavirus crisis.

Leading housing and care provider Blackwood is promoting a campaign to shine a light on the important front-line role care employees are playing – and to encourage businesses and individuals to look at ways they can show their gratitude.

Across Scotland, it is estimated that up to 150,000 staff work in the social care sector, providing care to people in care homes and retirement developments as well as care-at-home services.

Blackwood Chief Executive Fanchea Kelly said:  “Many older and vulnerable people could require hospital care without the help of our wonderful care staff. This vital support is happening in our communities in an almost invisible way during the COVID-19 crisis.

“In Blackwood we believe it is essential to recognise this important work publicly. We’d like to let care staff know that they are appreciated, keeping morale high at a time where many people are going way beyond their normal duties. If you can do anything to show your support, we’d love to hear from you.

“The first thing you can do is to join our campaign #ImInAwe so please tweet, retweet and share far and wide to get behind our carers and show how much they are valued.

“And I want to say thanks to members of Edinburgh Sports Club for volunteering to help drive our carers to their shifts as public transport services decrease.

“If you or your business can help in your own way, get in touch, we would love to hear from you to put a collective show of support across Scotland. But most importantly use ‘#ImInAwe‘ to show you care.”

Blackwood aims to help people live their life to the full, by providing services which support individuals to live independently. It specialises in technology and design innovation to support the role of its housing and care staff across Scotland.

For more information, please visit: https://www.blackwoodgroup.org.uk 

Update from Sainsbury’s Chief Executive Mike Coupe

I’ve written to you regularly over the past few weeks as we adapt the way we work to keep our shelves full while keeping you and our colleagues safe.

We continue to make changes in line with government guidelines and in response to feedback from you and our colleagues.

I am writing today to tell you about measures we are taking to protect our customers and colleagues and to update you on our product availability and on how we continue to support our elderly and vulnerable customers.

Keeping our customers and colleagues safe

Keeping you and our colleagues safe is our number one priority. This week we have brought in further measures to help you keep a safe distance from other customers and from our colleagues when you are visiting our stores.

We have queuing systems in place outside stores and ask you to please queue at a safe distance of two metres apart. Please also try to keep a safe distance from other customers and from our colleagues when you are doing your shop. We have placed clear markings on shop floors to help you know what a safe distance is.

From today, we are asking everyone to please only send one adult per household to our shops.

This helps us keep people a safe distance apart and also helps to reduce queues to get into stores. Our store teams will be asking groups with more than one adult to choose one adult to shop and will ask other adults to wait. Children are of course welcome if they are not able to stay at home.

To help keep our colleagues safe while serving customers, we now have screens at most manned checkouts. In the next few days we will have finished installing the screens across all manned checkouts in every supermarket, convenience store and Argos collection point.

Feeding the nation

We have been working hard with our suppliers to improve our product availability. Most people are now just buying what they need for themselves and their families. This means we now often have stock on the shelves all day and at the end of the day.

People have been queuing to get into our stores when they open in the mornings, but customers are now finding they can shop at any time of the day and feel confident in finding most of what they need.

As stock continues to build, we have been reviewing whether we still need to limit the number of items people buy. I am pleased to tell you that we will start to remove limits from Sunday. Limits will remain in place on the most popular items which include UHT milk, pasta and tinned tomatoes.

We have removed limits from Easter eggs immediately as we know families often want to buy more than three and we have plenty of these in all stores and online.

Supporting elderly and vulnerable customers

We are continuing to prioritise elderly and vulnerable customers for online delivery slots and our customer Careline has helped 170,000 customers, who will now get priority access to online delivery. In total, we have offered priority booking to more than 450,000 elderly or vulnerable customers.

I apologise to customers who have been struggling to get through to our online team. The team is working at full capacity and we are doing our very best to get to people as quickly as possible.

We are expanding our groceries online service as much and as quickly as we can. Two weeks ago we had 370,000 online grocery slots available. By the end of next week we will have increased this to 600,000 across home delivery and click and collect and we will continue to add more capacity over the coming weeks.

Supporting our colleagues

Our colleagues really are doing a remarkable job. I have been into a number of stores over the past few days and have been struck by their dedication and their determination to do the best job for our customers. These are very uncertain times and our colleagues really are on the frontline.

We are doing everything we can to keep our colleagues safe and this includes supporting them if they need to self-isolate. Where colleagues are considered vulnerable, we are paying them in full for the recommended 12 weeks self-isolation, including colleagues who live with extremely vulnerable family members who the government has asked to shield for 12 weeks.

I am personally committed to ensuring the safety of our colleagues and we will continue to do the right thing to protect them throughout this time.

I have been delighted to see that customers have told us they think colleague friendliness is at an all-time high at the moment. I think this is real testament both to the hard work of our colleagues and also the fantastic recognition they are getting for the vital role they are playing throughout this crisis.

Thank you for treating our colleagues with the respect and kindness they deserve. They really are doing their best to serve our customers well in these challenging times.

Best wishes

Mike

Entrepreneur aims to Keep Edinburgh Thriving

Pioneering venture Keep Edinburgh Thriving will allow residents to continue to ‘shop local’ whilst simultaneously supporting businesses across Edinburgh to survive COVID-19 and beyond 

Three weeks ago, everything changed overnight for small businesses across the city of Edinburgh. Social distancing measures forced them to close their doors indefinitely and the future for each of them, became somewhat uncertain.

In an attempt to provide these independent vendors with a much-needed lifeline, local entrepreneur, Robbie Allen has launched Keep Edinburgh Thriving, a service that will see a selection of local high-quality products packaged up into gift boxes and delivered to households across Scotland’s capital.

The pioneering venture will allow local residents to continue to ‘shop local’ whilst simultaneously providing a critical lifeline to these businesses, helping them with cash flow and financial sustainability during COVID-19 and beyond.

Robbie Allen, founder of Keep Edinburgh Thriving comments: “It is a really simple idea. Our aim is to Keep Edinburgh Thriving.

“We are partnering with a bunch of amazing local businesses in Edinburgh and taking these high-quality products and handling all the logistics and e-commerce side of things for them so that they can continue to grow and sustain their company and livelihood.

“This is a really tough time for our beloved high street, and we want to help as many local Edinburgh businesses as possible. As soon as you place an order this instantly benefits our local partners providing the products in each gift box.”

There are two box sizes of gift box available – a small box contains 4-5 items (£39) and a large contains 6-7 items (£55). Customers will receive a variety of products including artisan food and snacks, local art, drinks, craft coffee, beer, spirits, lifestyle products (candles, coasters, notebooks, mugs/tumblers) and local skin care products, all of which will be high-quality and local to Edinburgh.

To help support the local community further during this epidemic, £2 from each gift box sale will be donated to the Edinburgh Food Project.

The rapid spread of COVID-19 has caused a sudden, steep decline in business for cafes, restaurants, boutiques, artisans, creators and local retailers.

For more information about how to support your local high street and keep Edinburgh Thriving, visit www.keepedinburghthriving.com

National Express: Full suspension of Services from Midnight 5 April

National Express will fully suspend its national network of scheduled coach services with effect from midnight Sunday 5 April.

Chris Hardy, managing director of National Express UK Coach said: “We kept a limited coach network running to be able to help those individuals with essential travel needs but it is no longer viable to continue to do this.

“Passenger numbers continue to fall as the public rightly follow government advice to avoid non-essential travel. The decision to temporarily suspend all services is the right one based on the current unprecedented circumstances and I hope our passengers understand this.

“It is very clear that the critical thing we must do to protect our NHS and save lives is to stay at home. All journeys before Monday 6 April will be completed and we will ensure customers are not stranded but until further notice, we will not be running any services.”

Passengers who had travel booked can choose to hold the ticket and amend for future travel within the next 12 months, free of charge, regardless of the terms and conditions. Customers do not need to make contact until they wish to rebook.

For passengers who do not want this option, a full refund will be issued for cancelled services in line with terms and conditions.

Full details are available on the National Express website www.nationalexpress.com.

Chris Hardy added: “Our drivers, customer service teams, customer contact centre and the wider National Express team have been working incredibly hard to keep our services running safely and we thank them for their efforts.

“We are speaking to them about what this means and will continue to do all we can to support everyone who works in our business at this challenging time.

“We know this is a worrying time. We take the welfare of our customers and employees extremely seriously and will continue to take guidance from the Government to ensure we do everything we sensibly can to keep them safe.

“Regular updates will be provided through our website, social media channels and email alerts.

“When the time is right, we look forward to resuming services and welcoming customers back on board.”