Funding boost for ground-breaking cancer and Parkinson’s research team

Researchers at the University of Dundee to receive a government funding boost to continue their vital work for a further 5 years

  • Vital work by Dundee-based cell biology researchers, who have already developed a drug to treat skin cancer and attracted £60 million in private investment, to continue thanks to further government backing
  • Almost £30 million in government funding could potentially unlock new treatments for conditions, from motor neurone disease to Crohn’s, by supporting research into how signals are transmitted within the body’s cells. 
  • Science and Technology Secretary will announce funding at the Universities UK conference as he sets out his vision for harnessing the power of higher education to boost innovation and economic growth across the country.

Dundee-based researchers with a track record of devising treatments for deadly diseases like cancer and Parkinson’s – whose work has crowded in £60 million in investment to date – are receiving further backing from the government to continue their vital work for a further 5 years, Science and Technology Secretary Peter Kyle will announce today (Thursday 5 September). 

The Medical Research Council’s Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) will receive nearly £30 million of funding allocated from UKRI’s Medical Research Council (MRC) to bolster its cell biology research centre as it continues its vital work over the next 5 years. 

Currently, the 200-strong scientific community of staff and students based at the University of Dundee are using cutting-edge technology and biochemistry to explore how signals transmitted within the body’s cells are disrupted.

Working closely with industry, Dundee’s unit has been a fundamental part of the development and clinical approval of over 40 drugs that are now widely used to treat patients, attracting almost £60 million in private investment.

It is just one example cementing Scotland’s place at the forefront of the UK government’s plans to make Britain a powerhouse for life sciences that attracts international investment and drives forward the deployment of discoveries that grow the economy, create prosperity across the country and improve lives and public services.

Improving our understanding of the processes within cells could be the key to unlocking the scientific basis of innovative treatments for a range of diseases – from Alzheimer’s and Parkinson’s to Crohn’s and coeliac disease.  Their work has already delivered a drug that is now widely used to treat skin cancer.

The new funding comes ahead of the Science and Technology Secretary addressing higher education representatives at the Universities UK conference at the University of Reading, where he will reflect on his personal experience in higher education and will give his full-throated backing to the sector as a vehicle for much-needed economic growth.  

He will also outline his vision for DSIT, and the crucial role universities can play in this, harnessing discoveries and innovations for novel therapies and technologies, like those developed in Dundee, that could transform patients’ lives and drive economic growth.

Science and Technology Secretary Peter Kyle said: “I went to university later in life than most, but when I did it changed everything for me. It was the first time in my life that people saw potential in me that I never knew I had, and gave me the support and focus I needed to build something from it.

“The value of our universities, to the economy and to the whole of society, cannot be overstated. 

“As we embark on a decade of national renewal, the higher education sector has a profound role to play in every piece of work we’ll need to do, to build a Britain that delivers for working people: from seizing the potential of clean energy to rebuilding the NHS. I will always champion our universities.

“They are society’s most powerful engines for innovation, aspiration, economic growth and the creation of better lives for all – which is why investing in their work, like this £30m in funding, is so important.” 

Science Minister Lord Vallance said: “The work at the University of Dundee, which we are announcing support for today, is proof of how deep expertise, effective links with industry, and the power of curiosity can deliver meaningful improvements to people’s lives, while also driving economic growth across the UK.

“This funding puts the unit on track to strive for still more health breakthroughs, that could help more patients live longer and healthier lives.” 

Working with other companies, including GlaxoSmithKline, the team was central to developing a drug now widely used to treat melanoma, and a promising new drug for Parkinson’s disease is in clinical trials as a result of the team’s globally recognise work, investigating the condition to discover potential causes and treatments. 

Universities are vital to the government’s mission to boost our economy and transform healthcare services with world-class science and research. They are at the heart of our research strengths, underpinning key sectors including life sciences.

Backing university-based researchers, like the team at the University of Dundee, will ensure that they can continue unlocking the technologies and therapies that could be life-changing to patients, and which drive economic growth and productivity. 

Professor Dario Alessi, Director of the MRC PPU said: “We are incredibly grateful for the long-term support that our Unit has received from the MRC over the last 34 years.

“This has enabled our researchers to tackle the most important questions and greatly contributed to our understanding of how derailment of biological pathways causes human diseases including neurodegeneration, diabetes, cancer, and immune dysfunction.  

“Our mission for the next 5 years will be to work with leading research centres, clinicians, and pharmaceutical companies to translate our discoveries into clinical progress and accelerate drug discovery.

“Whilst doing this research we aim to provide our staff with a unique training opportunity working in a collaborative multidisciplinary environment paying attention to improving culture and development best practices.” 

Professor Patrick Chinnery, Executive Chair of the Medical Research Council, said:  “The MRC are proud to be investing for a further 5 years in the exceptional research of the MRC PPU in Dundee.

They are leaders in conducting rigorous fundamental research and then working with industry to translate those breakthroughs for patient benefit. The MRC PPU have an outstanding culture of collaboration and sharing their leading research expertise, products and techniques with the wider scientific community.” 

Swinney: We WILL deliver support for families

Programme for Government 2024-25

Eradicating child poverty, building prosperity, improving public services and protecting the planet will be the top priorities of the Scottish Government, First Minister John Swinney has pledged.

Outlining his first Programme for Government (PfG) as First Minister, Mr Swinney set out how the Scottish Government will deliver commitments that are ‘affordable, impactful and deliverable’.

The First Minister highlighted that child poverty is his ‘first and foremost’ priority and that he will reform support for whole family services to make them ‘easy to access, well-connected and responsive to families’ needs.’

Key announcements include:

  • the expansion of Fairer Future Partnerships ensuring services work to help families by maximising their incomes – supporting parents back into work and improving their wellbeing
  • ensuring the NHS has the resources it needs, today and in the years to come, freeing up 210,000 outpatient appointments and delivering around 20,000 extra orthopaedic, ophthalmology and general surgery procedures annually in Scotland’s new National Treatment Centres
  • making Scotland more attractive for investment and promoting home-grown entrepreneurs and innovators
  • delivering faster planning decisions for renewable energy schemes, protecting the planet by speeding up the transition to net zero

The First Minister said: “This Programme for Government will ensure that the people of Scotland have every opportunity to live well, thrive, and see promise in their future.

“This year’s commitments are affordable, impactful and deliverable. Together, they reflect my optimism that out of every challenge, we gain an invaluable opportunity to adjust our course, to interrogate our priorities and to renew our partnerships.

“I have been clear about the financial limitations surrounding this Programme for Government due to UK Government spending decisions. In the face of these significant challenges, it is critical that we direct available funding towards our four priorities – eradicating child poverty, building prosperity, improving our public services and protecting the planet.”

In his statement, the First Minister added: “No child should have their opportunities, their development, their health and wellbeing, and their future curtailed by the material wealth of their family.  Not ever, and certainly not, in a modern, prosperous society like Scotland.

“This is not only the moral compass of my Government, it is the greatest investment in our country’s future that we can possibly make.”

Reacting to the Programme for Government, Poverty Alliance chief executive Peter Kelly said: “It’s good that the First Minister talked about his strong commitment to ending the injustice of child poverty in our wealthy nation.

“But before today’s Programme for Government more than 100 of our members came together calling for action like boosting the Scottish Child Payment to £40 a week, affordable housing, and the delivery of stronger social security through a Minimum Income Guarantee. Many of these calls were not progressed within today’s Programme for Government.

“The First Minister was right to highlight the importance of welfare advice services that help people get the support they’re entitled to through social security. While a continued commitment to invest in the third sector is positive, the Scottish Government need to be clear as to how they will deliver long-standing promises for fair funding for the community and voluntary organisations that deliver that advice.

“He talked about affordable childcare and extra support to help people into work – but these commitments need to be matched with adequate investment. The Poverty and Inequality Commission have been clear that existing interventions are not at the scale necessary to deliver the change needed to meet our child poverty targets.

“He talked about closing the attainment gap in schools. But the latest figures show that children from poorer backgrounds are still being held back by poorer educational outcomes, so we need to hear what the Scottish Government is going to do differently.

“We welcome the fact that a Community Wealth Building Bill will be introduced into Parliament. But we need to make sure that it puts the voices of people in poverty at its heart, and starts to build new local economies that place wellbeing at their heart, and start to lessen Scotland’s unjust inequalities of wealth and power.

“We’re very disappointed that there will be no Human Rights Bill for Scotland. Poverty is a breach of people’s human rights, and we need to make sure they have the power to hold public bodies to account when their rights aren’t respected. The delay to this Bill will make it more difficult for the Scottish Government to deliver on their core mission of eradicating child poverty.

We are a country that believes in justice and compassion. People in Scotland want our political leaders to unlock our country’s vast wealth, build better budgets that give people the means to build a better future, and to create a true wellbeing economy that supports fair work, and a just transition to the net zero future that we urgently need.”

Read the Programme for Government 2024-25

Read the First Minister statement to the Scottish Parliament, 4 September 2024

INCOMPETENCE. DISHONESTY. GREED.

DAMNING GRENFELL TOWER INQUIRY REPORT PULLS NO PUNCHES

The Grenfell Tower Inquiry has published its second and final report into the
circumstances leading up to and surrounding the fire at Grenfell Tower in the early hours of 14 June 2017.

The publication of the Phase 2 report marks the end of a process that began on 15
June 2017 when then Prime Minister Theresa May announced a public inquiry to
examine the disaster with a view to ensuring that a similar disaster could never occur again. The fire at Grenfell Tower was the worst residential fire in the UK since the Second World War and resulted in the deaths of 72 people.

The Phase 1 report was published on 30 October 2019 and focused on the events of
14 June 2017: how the fire started, how it escaped from the flat where it had begun
and how it spread over the whole building with tragic consequences.

Phase 2 of the Inquiry examined the underlying causes of the fire to identify where
mistakes were made and how Grenfell Tower came to be in a condition which
allowed the fire to spread in the way identified by Phase 1. It also investigated the
response of the authorities to the emergency.

Introducing the report, Inquiry Chairman the Rt Hon Sir Martin Moore-Bick explained that the second part of the investigations had taken longer than originally hoped because, as those investigations progressed, the Inquiry uncovered many more matters of concern than had previously been expected:

The Inquiry report finds that the deaths that occurred were all avoidable “and that those who lived in Grenfell Tower were badly failed over a number of years by those who were responsible for ensuring the safety of its occupants.”

Sir Martin said: “They include the government, the Tenant Management Organisation, the Royal Borough of Kensington and Chelsea, those who manufactured and supplied the materials used in the refurbishment, those who certified their suitability for use on high-rise residential buildings, the architect, Studio E, the principal contractor, Rydon Maintenance Ltd, and some of its sub-contractors, in particular, Harley Curtain Wall Ltd and its successor Harley Facades Ltd, some of the consultants, in particular the fire engineer, Exova Warringtonfire Ltd, the local authority’s building control department and the London Fire Brigade,”

Sir Martin went on to explain that while not all of them bear the same degree of
responsibility for the eventual disaster, “all contributed to it in one way or another, in most cases through incompetence but in some cases through dishonesty and greed.”

Panel member and architect Thouria Istephan, who spent nearly 30 years as an
architect before joining the Inquiry in 2020, said: “Our report identifies what we think is needed to make sure that the legacy of Grenfell is real and brings about lasting change.

“Our recommendations place new burdens and responsibilities on people and organisations. I make no apologies for that: put simply, if you work in the construction industry and you do not feel the weight of the responsibility you have for keeping people safe – you are in the wrong job.”

Former housing association chief executive Ali Akbor OBE, who joined the Inquiry as a Panel Member in 2020, said: ““I hope that our report acts as a reminder to the clients of future building projects – including social housing providers – that they have a responsibility to the users of their buildings to ensure that safety is not sacrificed to the demands of speed and cost.

Mr Akbor concluded: “We cannot in a few words here today do full justice to the totality of our report. What is needed is for those with responsibility for building safety – in my sector as in Thouria’s – to read the report, to reflect on it, and to treat Grenfell as a touchstone in all that they do in the future. To act with professionalism, with competence, and to put people first.”

Recommendations put forward by the Inquiry panel include:

● bringing responsibility for all aspects of fire safety under one government
Department;
● the appointment of a construction regulator to oversee all aspects of the
construction industry;
● the establishment of a body of professional fire engineers, properly regulated
and with protected status and the introduction of mandatory fire safety
strategies for higher-risk buildings;
● a licensing scheme for contractors wishing to undertake the construction or
refurbishment of higher-risk buildings;
● the regulation and mandatory accreditation of fire risk assessors;
● the establishment of a College of Fire and Rescue to provide practical,
educational and managerial training to fire and rescue services.the introduction of a requirement for the government to maintain a publicly accessible record of recommendations made by select committees, coroners and public inquiries, describing the steps taken in response or its reasons for declining to implement them.

The Panel expressed its gratitude to all those who had supported the Inquiry through giving evidence and providing statements to assist its investigations, in particular the bereaved, survivors and residents of Grenfell Tower.

Grenfell Tower Inquiry opened on 14 September 2017. During the course of its
investigations it disclosed over 300,000 documents to 646 Core Participants,
obtained over 1500 witness statements and sat for more than 300 days, most of
which were devoted to taking evidence from a wide range of factual and expert
witnesses.

Prime Minister Keir Starmer’s statement in the House of Commons on Grenfell Tower Inquiry final report:

Mr Speaker, this morning Sir Martin Moore-Bick published the final report of the Grenfell Tower Inquiry.

And I am sure the whole House will join me in thanking him, the members of the Inquiry and his whole team for their dedicated work.

Mr Speaker, I want to speak directly to the bereaved families, the survivors, and those in the immediate Grenfell community…

Some of whom are with us in the gallery today. 

Sir Martin concluded this morning – I’m afraid there is no way of repeating this that won’t be painful – “the simple truth is that the deaths that occurred were all avoidable and that those who lived in the tower were badly failed over a number of years and in a number of different ways”  by, as the report lays out in full, just about every institution responsible for ensuring their safety.

Mr Speaker, in the face of an injustice so painful. So deserving of anger

Words begin to lose their meaning. 

Seven years – still waiting

For the justice you deserve.

I want to say very clearly, on behalf of the country: you have been let down so badly before, during and in the aftermath of this tragedy. 

And while Sir Martin sets out a catalogue of appalling industry failures, for which there must now be full accountability, he also finds – and I quote – “decades of failure by central government.”

He concludes that “In the years between the fire at Knowsley Heights in 1991 and the fire at Grenfell Tower in 2017 there were many opportunities for the government to identify the risks posed by the use of combustible cladding panels and insulation

And he concludes – and I quote – “By 2016 the department was well aware of those risks, but failed to act on what it knew.”

Further, he finds that “The department itself was poorly run”  and “the government’s deregulatory agenda dominated the department’s thinking to such an extent that even matters affecting the safety of life were ignored, delayed or disregarded”. 

So Mr Speaker, I want to start with an apology on behalf of the British state to each and every one of you and indeed to all the families affected by this tragedy. It should never have happened. 

The country failed to discharge its most fundamental duty to protect you and your loved ones: the people we are here to serve. And I am deeply sorry.

I also want to express my admiration for the strength it must have taken to relive those events when giving your evidence to this Inquiry.

And indeed, to see written down today the circumstances that led to the deaths of your loved ones. 

After all you have been through, you may feel you are always just one step away from another betrayal. 

I get that – and I know I cannot change that with just words today. 

But what I can say is that I listened carefully to one of the members of the inquiry Ali Akbor who said this morning: “What is needed is for those with responsibility for building safety to reflect and to treat Grenfell as a touchstone in all that they do in the future.”

Mr Speaker, I consider myself responsible for building safety. And that is exactly what I will do. And what I will demand of this government.

Mr. Speaker, today is a long-awaited day of truth – but it must now lead to a day of justice. Justice for the victims and families of Grenfell. 

But also a moment to reflect on the state of social justice in our country and a chance for this Government of Service to turn the page. 

Because this tragedy poses fundamental questions about the kind of country we are.

A country where the voices of working class people and those of colour have been repeatedly ignored and dismissed. 

A country where tenants of a social housing block in one of the richest parts of the land are treated like second class citizens. 

Shamefully dismissed – in the words of one survivor – as people with needs and problems… Not respected as citizens, as people who contribute to Britain, who are part of Britain, who belong in Britain. 

And Mr Speaker, unbelievably this continued even after the tragedy.

Sir Martin highlights…and I quote – “Certain aspects of the response demonstrated a marked lack of respect for human decency and dignity and left many of those immediately affected feeling abandoned by authority and utterly helpless.”

Mr Speaker, that alone should make anyone who feels any affinity towards justice bristle with anger. But Sir Martin continues. He finds – and these are his words – “systematic dishonesty on the part of those who made and sold the rainscreen cladding panels and insulation products

And he goes on to say: “They engaged in deliberate and sustained strategies to manipulate the testing process, misrepresent test data and mislead the market.” 

Sir Martin also cites – “A complete failure on the part of the Local Authority Building Control over a number of years to take basic steps to ensure that the certificates it issued were technically accurate.” 

He finds that the work of the Building Research Establishment “..was marred by unprofessional conduct, inadequate practices a lack of effective oversight, poor reporting and a lack of scientific rigour.”   And that the Tenant Management Organisation “must also bear a share of the blame

Its only fire safety assessor “had misrepresented his experience and qualifications (some of which he had invented) and was ill-qualified to carry out fire risk assessments on buildings of the size and complexity of Grenfell Tower.” 

He also finds – “a chronic lack of effective management and leadership” on behalf of the London Fire Brigade” With tragic consequences on the night of the fire. 

Mr Speaker, in the light of such findings it is imperative that there is full accountability, including through the Criminal Justice process, and that this happens as swiftly as possible.

So I can tell the House today that this government will write to all companies found by the Inquiry to have been part of these horrific failings as the first step to stopping them being awarded government contracts.

And, of course, we will support the Met Police and the prosecutors as they complete their investigations.

But, Mr Speaker, it is vital that as we respond to this report today we do not do or say anything that could compromise any future prosecution. 

Because the greatest injustice of all would be for the victims and all those affected not to get the justice they deserve.

Mr Speaker, there must also be much more radical action to stop something like this from ever happening again.  

Because one of the most extraordinary qualities of the Grenfell community is their determination to look forward.

They are not only fighting for justice for themselves, they are fighting to ensure no other community suffers as they have done. 

Mr Speaker, some important reforms have been made over the last seven years.

Reforms we supported in Opposition. 

Including banning combustible cladding.

New oversight of building control.

A new safety regime for all residential buildings over 18 metres.

New legal requirements on social landlords.

Making sure Fire and Rescue Services are trained and equipped to handle large scale incidents. including moving from “stay put” to “get out” when needed.

And we are now addressing the recommendation from Sir Martin’s first report: to introduce a new Residential Personal Emergency Evacuation Plan policy for anyone whose ability to evacuate could be compromised and funding this for those renting in social housing.

Mr Speaker, we will look at all 58 of Sir Martin’s recommendations in detail.

There will be a debate on the floor of this House. 

We will respond in full to the Inquiry’s recommendations within six months.

And we will update Parliament annually on our progress against every commitment we make. 

But there are some things I can say right now. There are still buildings today with unsafe cladding. And the speed at which this is being addressed is far, far too slow. 

We only have to look at the fire in Dagenham last week. A building that was still in the process of having its cladding removed. So this must be a moment of change. 

We will take the necessary steps to speed this up. 

We are willing to force freeholders to assess their buildings and enter remediation schemes within set timetables with a legal requirement to force action if that is what it takes to tackle industry intransigence. 

And we will set out further steps on remediation this Autumn.

We will also reform the construction products industry that made this fatal cladding so homes are made of safe materials and those who compromise that safety will face the consequences. 

We will ensure that tenants and their leaseholders can never again be ignored. And that Social landlords are held to account for the decency and safety of their homes.

And as this government tackles the most acute housing crisis in living memory, building one and a half million new homes across the country, we will ensure these homes are safe, secure, and built to the highest standards. 

Places of security, health and wellbeing that serve the needs of residents and their wider communities. Because a safe and decent home is a human right and a basic expectation and the provision of that right, should never be undermined by the reckless pursuit of greed. 

One of the tragedies of Grenfell is that this was – and is – a community that nurtured so much of what we want from housing.

People who had made the Tower their home. And were entitled to a place of safety and security not a death-trap. And yet time and again they were ignored.

Mr Speaker, two weeks ago I made a private visit to Grenfell Tower. I laid a wreath at the Memorial Wall and affirmed the government’s commitment to the work of the Memorial Commission. Delivering a permanent memorial on the site through a process led by the Grenfell community.

As I walked down that narrow staircase from the 23rd floor and looked at walls burned by 1000-degree heat I got just a sense of how utterly, utterly terrifying it must have been.

And as I saw examples of the cladding on the outside of the building, and listened to descriptions of the catastrophic and completely avoidable failures of that fatal refurbishment.

I felt just a sense of the anger that now rises through that building. And it left me a with a profound and very personal determination. To make the legacy of Grenfell Tower one of the defining changes to our country that I want to make as Prime Minister.

To the families, the survivors, and the immediate community We will support you now and always, especially those who were children. In the memory of your loved ones we will deliver a generational shift in the safety and quality of housing for everyone in this country.

And in the memory of Grenfell, we will change our country. Not just a change in policy and regulation – although that must of course take place – but a profound shift in culture and behaviour.

A rebalancing of power that gives voice and respect to every citizen, whoever they are, wherever they live.

And Mr Speaker, we will bring the full power of government to bear on this task.

Because that is the responsibility of service. 

And the duty we owe to the memory of every single one of the 72.

And in that spirit, I commend this statement to the House.

A STATEMENT FROM THE METROPOLITAN POLICE:

GRENFELL UNITED CAMPAIGNERS SAID:

FOR THE FAMILIES OF THOSE WHO DIED AND A COMMUNITY THAT WAS IGNORED FOR FAR TOO LONG, LET’S HOPE THIS REPORT IS JUST THE BEGINNING IN THE FIGHT FOR JUSTICE. THIS STORY IS FAR FROM OVER.

= more to follow =